TY - JOUR AU - ALONSO CANAL, LAURA AU - CARRERAS SÁEZ, INMACULADA AU - Fournier del Castill, María de la Concepci AU - Asensio Antón, Julia AU - de Prada Vicente, Inmaculada AU - Isasi Zaragoza, Carlos AU - Tejada Gallego, Jose Javier AU - Martínez-Gómez, María José PY - 2019 DA - 2019/04/03 TI - <b>Gluten-Free Diet for the Treatment of ADHD; Pilot Study </b> JO - OBM Neurobiology SP - 024 VL - 03 IS - 02 AB - Aim: The association between Attention deficit hyperactivity disorder (ADHD) and celiac disease has already been established. Non-celiac gluten sensitivity (NCGS), as well as celiac disease, has been associated with neuro-psychiatric disorders. Our objective is to assess if a proportion of pediatric ADHD patients are affected by NCGS and could, consequently, benefit from a gluten-free diet. Material and methods: Pilot study of 6 ADHD patients. Personal or family history suggestive of NCGS was investigated. The Conners Continuous Performance Test II (CPT-II) was performed to assess the ADHD clinical picture. Celiac serology and celiac susceptibility HLA blood analysis was performed, as well as upper gastrointestinal endoscopy. Regardless of the results obtained, everyone followed a gluten-free diet for 4 months. After this time, patients and their relatives were questioned about changes experienced in the symptomatology and a new CPT-II was performed. Results: The 6 patients presented digestive symptoms and 2 reported headache. Celiac serology was negative in all patients. Four patients had iron deficiency. Four patients were DQ2+. In addition, 5 patients had gastritis due to H. Pylori. All patients reported the disappearance of the digestive symptoms and headaches disappeared in the 2 affected patients. 3 patients confirmed improvement in ADHD symptomatology. No statistically significant changes were observed when comparing the results in the CPT-II pre- and post-intervention. Conclusions: Patients with ADHD seemed to improve their gastrointestinal symptoms with a gluten-free diet and, on occasion, also their ADHD symptoms. Non-celiac gluten sensitivity should be ruled out in ADHD patients. SN - 2573-4407 UR - https://doi.org/10.21926/obm.neurobiol.1902024 DO - 10.21926/obm.neurobiol.1902024 ID - ALONSO CANAL2019 ER -