TY  - JOUR
AU  - Greenlaw, Kirsten
AU  - Shiva Shankar, Jai Jai
PY  - 2019
DA  - 2019/01/13
TI  - Correlation of CT and MR Perfusion and Permeability Parameters for Intracranial Tumors
JO  - OBM Neurobiology
SP  - 019
VL  - 03
IS  - 01
AB  - Background and Purpose: Perfusion imaging, mainly MR perfusion (MRP), is performed frequently for brain tumor imaging. CT perfusion (CTP) is less studied as a method for characterizing brain tumors. The purpose of this study was to demonstrate the usefulness of CTP perfusion parameters in evaluating brain tumors and to compare it with MRP measures in the same patient population.
Methods: Patients underwent CTP and MRP imaging prospectively. Images were processed with vendor-provided and vendor-neutral software. Four regions of interests were placed in whole tumor, solid portion of the tumor, region of maximum perfusion and contralateral normal white matter. Absolute and normalized values of cerebral blood flow (CBF), cerebral blood volume (CBV), and permeability were obtained for both CTP and MRP and compared using correlation and linear regression.
Results: We compared CTP and MRP in 20 patients with intracranial tumors. With vendor-provided software, we found significant correlation for absolute CBV in the region of maximum perfusion (r=0.49, p=0.031) and for normalized CBV (r=0.25, p=0.020) and normalized CBF (r=0.49, p=0.011) in the whole tumor. With vendor-neutral software, we found significant correlation for normalized CBF in whole tumor (r=0.29, p=0.013) and in solid component (r=0.29, p=0.012). There were no significant correlations for the permeability parameters.
Conclusion: In comparing CTP and MRP methods, several statistically significant positive correlations were seen for CBF and CBV values. CTP may potentially be used interchangeably with MRP, for imaging of brain tumors, especially when MRP is contraindicated.
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.1901019
DO  - 10.21926/obm.neurobiol.1901019
ID  - Greenlaw2019
ER  -