TY - JOUR AU - Shankar, Jai Jai Shiva AU - Bata, Adil AU - Sinha, Namita PY - 2018 DA - 2018/10/25 TI - Isolated Diffusion Restriction Preceding Contrast Enhancement in Glioblastoma Multiforme is Associated with Short-Term Survival JO - OBM Neurobiology SP - 013 VL - 02 IS - 04 AB - Background: Current imaging standard for detecting and assessing glioblastoma multiforme (GBM) progression depends on contrast-enhancement on brain magnetic resonance imaging (MRI). Isolated foci of diffusion restriction have been observed to precede enhancement in GBM. The aim of our study was to investigate the frequency of isolated diffusion restriction that precede corresponding enhancement and to investigate if isolated diffusion restriction was associated with survival in patients with GBM. Methods: MRI of the brain, including diffusion weighted images (DWI) and apparent diffusion coefficient (ADC) maps, of 102 consecutively treated patients with histopathologically confirmed GBM were retrospectively examined. Images were assessed for the presence of isolated diffusion restriction in GBM and identified lesions were monitored for enhancement on follow-up MRI. Data were collected on the length of time for enhancement to appear, normalized ADC, and overall survival of patients. Results: Forty patients (39.2%) showed areas of isolated diffusion restriction. Ten patients (25%) developed corresponding enhancement on follow-up imaging after an average of 145 days after the index imaging. In patients with isolated restricted diffusion, the mean ADC was 721.4 ± 117.2 mm2/s compared to 888.7 ± 85.2 mm2/s in the normal appearing-white matter (NAWM) in contralateral hemisphere (p SN - 2573-4407 UR - https://doi.org/10.21926/obm.neurobiol.1804013 DO - 10.21926/obm.neurobiol.1804013 ID - Shankar2018 ER -