TY - JOUR AU - Lopes-Martins, Rodrigo Alvaro Brandão AU - Leonardo, Patrícia Sardinha AU - Mannoia, Kevin PY - 2025 DA - 2025/06/18 TI - Physicality of Spirituality: The Interplay of the Autonomic Nervous System, Prefrontal Cortex, and Spiritual Life in Light of Galatians 5:16-25 JO - OBM Integrative and Complementary Medicine SP - 025 VL - 10 IS - 02 AB - This article examines the complex relationship between the autonomic nervous system, the prefrontal cortex, and spiritual life, providing an interdisciplinary analysis in light of Galatians 5:16-25. Through a combination of theological reflection and insights from neuroscience, it explores how spiritual practices, such as meditation and prayer, influence emotional regulation, impulse control, and overall well-being. Studies in neuroscience have shown that regular spiritual practice can lead to measurable changes in the brain, such as increased cortical thickness in the prefrontal cortex, enhancing self-control and emotional resilience. Building on these scientific findings, the article introduces the concept of the “spirituality of physicality,” which affirms the deep connection between bodily health and spiritual well-being. Drawing parallels between the regulation of the sympathetic and parasympathetic nervous systems and the struggle between the flesh and the Spirit described by Paul, the article suggests that spiritual growth and physiological health are intricately linked. It highlights how cultivating a balanced spiritual life influences both the body and mind, promoting virtues such as self-control, patience, and peace. The article concludes by emphasizing the importance of further research on the connection between physical health and spiritual practices, offering a fresh perspective for theological and scientific communities. This holistic view challenges traditional dichotomies between body and spirit, presenting a vision of integrated human flourishing through the harmony of faith, neuroscience, and physiology. SN - 2573-4393 UR - https://doi.org/10.21926/obm.icm.2502025 DO - 10.21926/obm.icm.2502025 ID - Lopes-Martins2025 ER -