TY  - JOUR
AU  - Tecce, Mario F.
AU  - Milano, Walter
AU  - Capasso, Anna
PY  - 2020
DA  - 2020/08/31
TI  - Health Benefits of Green Tea in Obesity
JO  - OBM Integrative and Complementary Medicine
SP  - 038
VL  - 05
IS  - 03
AB  - Adipocytes play a central role in maintaining lipid homeostasis and energy balance by storing triacylglycerols (TAGs) or releasing free fatty acids in response to changes in energy requirements. Obesity is a major risk factor for many diseases, including diabetes, hypertension, and cardiovascular disease. Besides, morbidity and mortality associated with being overweight and obese are on the rise. The development of obesity is characterized by an increase in lipid cells due to mitogenesis and differentiation, which are regulated by genetic, endocrine, metabolic, neurological, pharmacological, environmental, and nutritional factors. Therefore, understanding the mechanism by which a given nutrient affects the mitogenesis of preadipocytes and their differentiation into adipocytes could help prevent the onset and progression of obesity, along with all its consequences in humans. It has been shown that nutraceuticals such as tea catechins and BCAAs (leucine, isoleucine, and valine) could be effective in preventing obesity. Green tea catechins (CTGs) are polyphenolic flavonoids, which were previously called vitamin P. CTGs, especially EGCGs, have been shown to reduce body weight and body fat. In support of its anti-obesity effect, some in vivo data have shown that EGCG or green tea extract containing EGCG reduces the absorption of food, lipids, TAGs, cholesterol, and leptins. Furthermore, it stimulates energy expenditure and fat oxidation, and ultimately increases the level of high-density lipoproteins and fecal excretion of lipids. EGCG regulates various enzymes linked to anabolism and lipid catabolism, such as acetyl-CoA carboxylase (ACC), fatty acid synthase, pancreatic lipase, gastric lipase, and lipoxygenase; it also reduces the increase in insulin (INS) and TAG during the differentiation period of nine days. Taken together, these observations, in vivo and in vitro, suggest that the EGCG contained in green tea can modulate the mitogenic, endocrine, and metabolic functions of fat cells. In this study, we report the biochemical and biological evidence indicating the benefits of green tea in obesity.
SN  - 2573-4393
UR  - https://doi.org/10.21926/obm.icm.2003038
DO  - 10.21926/obm.icm.2003038
ID  - Tecce2020
ER  -