TY  - JOUR
AU  - Morin-Alain, Valérie
AU  - Larouche, Eddy
AU  - Chouinard, Anne-Marie
AU  - Audet, Marie-Claude
AU  - Goulet, Sonia
AU  - Rousseau, Louis-Simon
AU  - Hudon, Carol
PY  - 2020
DA  - 2020/04/17
TI  - Effects of a Mindfulness-Based Intervention on Circulating Cytokine Levels in Individuals with Amnestic Mild Cognitive Impairment: A Pilot Study
JO  - OBM Integrative and Complementary Medicine
SP  - 022
VL  - 05
IS  - 02
AB  - Peripheral inflammation plays an important role in the pathophysiology of Alzheimer’s disease (AD) and dysregulations in circulating levels of different inflammatory mediators are detectable as early as the mild cognitive impairment (MCI) stage towards AD. Depressive symptoms, another risk factor of AD, are often found in individuals with MCI and associated with heightened levels of peripheral inflammatory mediators. Diminution in depressive symptoms and alterations of peripheral inflammation profiles have been observed following Mindfulness-based interventions (MBIs). In this pilot randomized-control trial, the impact of a mindfulness-based intervention (MBI) was compared to that of a psychoeducation-based intervention (PBI) on the peripheral inflammation profile and depressive symptomatology of participants with MCI. Plasma samples and scores on the Geriatric Depression scale (GDS) were obtained from 12 participants per group before and after the 8-week interventions. Flow cytometry allowed for inter-group comparisons of the pro-inflammatory cytokines Interleukin (IL)-6 and Tumor Necrosis Factor (TNF)-α levels. Post-MBI, two tendencies stand out regarding inflammation profiles: 1) a decrease of TNF-α for participants having higher initial levels of this cytokine, and 2) an increase of IL-6 levels for all participants. In the PBI group, the cytokine levels remained unchanged post-intervention. Regarding depressive symptomatology, no significant variations were noted for both groups. Moreover, variations on depressive symptoms and peripheral levels of cytokines were not correlated. MBI could exert a physiological effect on an important feature of AD, namely inflammation. Furthermore, action mechanisms behind physiological and psychological effects of MBIs could stem from independent sources. This remains to be demonstrated with more robust data.
SN  - 2573-4393
UR  - https://doi.org/10.21926/obm.icm.2002022
DO  - 10.21926/obm.icm.2002022
ID  - Morin-Alain2020
ER  -