TY  - JOUR
AU  - Mizuno, Hideya
AU  - Taketomi, Ayako
AU  - Nakabayashi, Toshikatsu
PY  - 2018
DA  - 2018/09/27
TI  - Potentially Beneficial Effects of St. John’s Wort (Hypericum perforatum) in Patients with Metabolic Syndrome
JO  - OBM Integrative and Complementary Medicine
SP  - 021
VL  - 03
IS  - 03
AB  - St. John’s wort (SJW), or Hypericum perforatum, is a perennial herb that is used for the treatment of depression in several countries. However, its effects in other common conditions, such as the metabolic syndrome, have not been elucidated. Some studies have investigated the effects of SJW extract on differentiation of adipocytes, inflammation, and glucose metabolism. In this review, we summarize these studies and show the following: SJW enhances differentiation of adipocytes via activation of peroxisome proliferator-activated receptor gamma and increases expression of adiponectin; SJW exerts anti-inflammatory effects by inhibiting expression of pro-inflammatory adipokines; and SJW improves glucose metabolism by increasing insulin sensitivity and insulin secretion. Although further investigation is necessary, SJW may help to attenuate the pathologic process associated with the metabolic syndrome.
SN  - 2573-4393
UR  - https://doi.org/10.21926/obm.icm.1803021
DO  - 10.21926/obm.icm.1803021
ID  - Mizuno2018
ER  -