Welcome to the new academic journal OBM Hepatology and Gastroenterology. Recent progress in understanding liver, biliary, pancreatic and gastro-intestinal diseases and their treatments has been observed in the world. OBM Hepatology and Gastroenterology publishes interesting and informative reviews, original articles, and invaluable case reports in this area. We also publish basic research as well as clinical research.

Hepatitis A virus (HAV), HBV, HCV, HDV, and HEV are still a serious issue worldwide. Treatments on these viruses have recently improved. However, liver fibrosis, cirrhosis and hepatocellular carcinoma are still critical conditions. We focus on all of these liver diseases. We also focus on broad-spectrum of gastro-intestinal diseases in this journal.

Please accept our special thanks for choosing to publish in the OBM Hepatology and Gastroenterology. We are looking forward to your submissions for OBM Hepatology and Gastroenterology.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 6.8 days from acceptance to publication (median values for papers published in this journal in 2020, 1-2 days of FREE language polishing time is also included in this period).

Free Publication in 2023
Current Issue: 2022  Archive: 2021 2020 2019 2018 2017

Special Issue

Pathology and Management of Cirrhosis

Submission Deadline: January 31, 2019 (Open) Submit Now

Guest Editor

Tatsuo Kanda, MD, PhD

Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, Japan

Website | E-Mail

Research Interests: hepatology; gastroenterology; infectious diseases; viral hepatitis

About This Topic

In general, cirrhosis seems to be irreversible condition and progress to end-stage liver diseases. Hepatocellular carcinoma often occurs in cirrhosis of the liver. It is still unknown whether it is different reversibility between compensated and decompensated cirrhosis although direct-acting antivirals against hepatitis C virus have appeared. In recent, treatment for cirrhosis other than transplant has also been developing. In this special issue of OBM Hepatology and Gastroenterology, we welcome any manuscripts concerning all aspect of liver cirrhosis such as pathology, treatment as well as hepatocellular carcinoma.

Planned Papers

Title:Platelets in liver cirrhosis
Author:Paola Romecín, Ana I. García-Guillén, Joaquín García-Estañ *, Noemí M. Atucha
Affiliation:Depto. Fisiología, Fac. Medicina, 30120 Murcia, Spain
Keywords :Cholestasis; Calcium; Thrombin; Liver cirrhosis; Nitric oxide; Oxidative stress

Title:Optimising Surveillance Strategy in Patients with Cirrhosis
Author:Shariff Mohamed
1. Consultant in Gastroenterology & Hepatology; West Hertfordshire Hospitals NHS Trust
2. Gastroenterology Department, Watford General Hospital, Watford

Title:NASH and HCC
Authors: Behnam Saberi; Soohwan Chun, Aryana Chan, Douglas Dieterich
Affiliation: Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Title: Surgical strategies for centrally located hepatocellular carcinoma.
Author: Emilio De Raffele et al.
Affiliation: Dipartimento dell’ Apparato Digerente, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola-Malpighi, Bologna, Italy

Title: Long-term complications of radio-frequency thermal ablation of hepatocellular carcinoma. A case Report.
Author: Emilio De Raffele et al.
Affiliation: Dipartimento dell’ Apparato Digerente, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola-Malpighi, Bologna, Italy

Title:The Rational Use of Diuretics in the Management of Cirrhotic Ascites
Authors: Masaaki Takamura, Shuji Terai
Affiliation: Division of Gastroenterology and Hepatology, Graduate School of Medical and Denithtal Science, Niigata University, Niigata, Japan

Title: Fibrosis progression in NASH
Author: Jee-Fu Huang
Affiliation: Kaohsiung Medical University Hospital, Takau (Kaohsiung) City, Taiwan

Title: Triggers of splanchnic angiogenesis in portal hypertension
Authors: Nikolay Arefyev 1, Dmitry Garbuzenko 2
1. Department of Pathological Anatomy and Forensic Medicine, South Ural State Medical University, Chelyabinsk, Russia
2. Prof., MD, Ph.D., Department of Faculty Surgery, South Ural State Medical University, Chelyabinsk, Russia

Title: Management of Autoimmune hepatitis
Author: Alan Bonder
Affiliation: Division of GI and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA


Open Access Review

Low Prevalence of Spontaneous Bacterial Peritonitis in Ambulatory Asymptomatic Cirrhotic Patients: Consequences in Patients’ Care

Received: 21 August 2019;  Published: 15 April 2020;  doi: 10.21926/obm.hg.2002045


The literature on the prevalence of spontaneous bacterial peritonitis (SBP) in cirrhotic outpatients who visited the hospital for therapeutic abdominal paracentesis was reviewed in order to assess the usefulness of urinary strips in this setting. The authors reviewed the studies published as peer-reviewed articles on the prevalence of SBP [...]
Open Access Review

Platelet Function in Experimental Models of Liver Cirrhosis

Received: 15 May 2019;  Published: 01 November 2019;  doi: 10.21926/obm.hg.1904039


(1) Background: Platelet function is commonly altered in liver cirrhosis. In experimenta models of liver cirrhosis we have analyzed the mechanisms of this defective function. (2) Methods: Experiments were performed in a model of liver cirrhosis by bile duct-ligation in washed platelets by means of fluorescence spectroscopy with fura-2. (3 [...]
Open Access Review

Therapeutic Strategies and Current Management for Hepatic Encephalopathy in Liver Cirrhosis

Received: 04 February 2019;  Published: 16 July 2019;  doi: 10.21926/obm.hg.1903027


Hepatic encephalopathy (HE) is a neuropsychiatric syndrome showing a wide spectrum and one of the serious complications seen in patients with acute and chronic liver disease or spontaneous portal-systemic shunting. Recently, HE has been classified into two categories: covert HE, which involves minimal HE and is identified solely through ps [...]
Open Access Review

The Rational Use of Diuretics in the Management of Cirrhotic Ascites in Japan

Received: 04 February 2019;  Published: 25 April 2019;  doi: 10.21926/obm.hg.1902018


In cirrhosis, portal hypertension and hypoalbuminemia due to decreased albumin synthetic capacity and hormonal imbalance due to increased renin-angiotensin-aldosterone and vasopressin systems cause fluid retention and electrolyte abnormalities. Diuretics are indispensable for the control of body fluid volume in liver cirrhosis, and aldosterone [...]
Open Access Original Research

Association between Liver Stiffness and Gastro-Esophageal Varices in Chronic Liver Diseases

Received: 12 November 2018;  Published: 27 December 2018;  doi: 10.21926/obm.hg.1804012


Objective: Elastography is a non-invasive examination method that can estimate the extent of liver fibrosis, measured as liver stiffness (LS). We examined the relationship between gastro-esophageal varices and the LS and how to predict esophageal varices and varices bleeding by LS. Methods: From 2014 to 2016, we conducted a retrospective stud [...]
Open Access Original Research

Taste Impairment and Compliance Improvement of Branched-Chain Amino Acids in Patients with Liver Cirrhosis

Received: 25 September 2018;  Published: 26 December 2018;  doi: 10.21926/obm.hg.1804011


Background: Branched-chain amino acids (BCAA) are nutrients with a bitter taste, which causes low compliance in patients who need BCAA supplementation. Moreover, chronic liver disease is frequently complicated by taste impairment. The present study was designed to improve patient noncompliance regarding nutrients in liver disease. Methods: [...]