Table of Contents

Volume 4,Issue 3

Open Access Case Report

Porto-Sinusoidal Vascular Disease with Obliterative Portal Venopathy Associated with Long-Term Azathioprine for Crohn’s Disease

Received: 04 March 2020;  Published: 25 September 2020;  doi: 10.21926/obm.hg.2003051


Patients receiving immunosuppressive therapy for inflammatory bowel disease may be susceptible to non-cirrhotic portal hypertension, now referred to as porto-sinusoidal vascular disease. Here we describe a patient treated with long-term azathioprine for Crohn’s disease who developed porto-sinusoidal vascular disease with obliterative portal venopathy without nodular regenerative hyperplasia on histology. Specific signs of portal hypertension were present, including porto-systemic collaterals on [...]

Open Access Review

Human Gut Microbiota: Friend or Foe?

Received: 06 March 2020;  Published: 07 August 2020;  doi: 10.21926/obm.hg.2003050


The human gut is a house to approximately 1,000 different species of bacteria. The bacterial composition of gut microbiota is influenced by several factors, including age, sex, mode of delivery, geographical location, ethnicity, diet, drugs, and administration of prebiotics and/or probiotics. Similarly, human health depends on the composition of gut microbiome, with gut bacteria playing a crucial role in human physiology. For instance, gut microbiota synthesizes vitamins and amino acids, and aff [...]

Open Access Review

Use of Organs from Hepatitis C Viremic Donors: Addressing the Needs of a Changing Waitlist and the Effect of a Public Health Crisis

Received: 14 May 2020;  Published: 20 July 2020;  doi: 10.21926/obm.hg.2003049


The combination of broad screening initiatives and development of effective antiviral therapies have led to a revolution in the treatment of hepatitis C virus and has reduced the proportion of patients with the virus who develop a need for liver transplantation in favor of other etiologies, such as alcohol-related liver disease and non-alcoholic steatohepatitis. However, the opioid epidemic and rise in injection drug use in the United States has simultaneously led to otherwise healthy hepatitis [...]