TY  - JOUR
AU  - Hundal, Jasmin
AU  - AlHilli, Mariam
PY  - 2025
DA  - 2025/03/19
TI  - Improving Outcomes in Elderly Patients with Ovarian and Pancreatic Cancer through Multimodal Prehabilitation
JO  - OBM Geriatrics
SP  - 304
VL  - 09
IS  - 01
AB  - Elderly patients with ovarian and pancreatic cancer frequently experience malnutrition and sarcopenia, which negatively impact treatment tolerance, functional outcomes, and survival. The increasing use of neoadjuvant chemotherapy in this population necessitates structured interventions to mitigate these challenges. While prehabilitation has shown promise in enhancing treatment tolerance and quality of life, its role during chemotherapy remains underexplored. This prospective study evaluates the feasibility and impact of a multimodal prehabilitation program for elderly patients (≥65 years) with ovarian or pancreatic cancer undergoing neoadjuvant chemotherapy. The intervention consists of a 9-week structured program incorporating supervised aerobic and resistance exercises, individualized nutritional support (protein supplementation and dietary counseling), and psychosocial interventions (counseling and stress management strategies). Feasibility will be assessed through recruitment rates, adherence levels, and patient-reported satisfaction scores. Secondary outcomes include changes in physical function (6-minute walk test, grip strength, chair stand test), body composition (CT-derived muscle mass and sarcopenia markers), perioperative and chemotherapy-related complications (dose reductions, hospitalizations, and adverse events), and patient-reported outcomes (quality of life, fatigue, anxiety, and depression scores). We hypothesize that patients completing the prehabilitation program will demonstrate improved functional capacity, reduced treatment-related toxicities, and enhanced chemotherapy tolerance compared to baseline. Additionally, we anticipate that prehabilitation will lead to preserved muscle mass, decreasing rates of chemotherapy dose modifications, and improved post-treatment recovery. This study will provide critical insights into the feasibility of integrating multimodal prehabilitation into routine oncology care. It will serve as a foundation for future randomized controlled trials to optimize outcomes in this high-risk population.
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.2501304
DO  - 10.21926/obm.geriatr.2501304
ID  - Hundal2025
ER  -