TY  - JOUR
AU  - Cocco, Giuseppe
AU  - Pandolfi, Stefano
PY  - 2023
DA  - 2023/10/11
TI  - Age-Related Pathologies and Life Span
JO  - OBM Geriatrics
SP  - 253
VL  - 07
IS  - 04
AB  - Both from a healthcare and a socioeconomic perspective, research on senescence is increasingly essential. Indeed, in industrialized countries, the increased human longevity confronts medicine with many old patients with age-related pathologies. The paper reviews the biological theories on aging, the impact of reactive oxygen species, telomers, epigenetics, and genetics (e.g., gerontogenes) on-age-related pathologies. Also, the paper reviews available and under research therapeutic approaches (e.g., senolytics) aimed to prolong life span and reduce the morbidity related to old age.
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.2304253
DO  - 10.21926/obm.geriatr.2304253
ID  - Cocco2023
ER  -