TY  - JOUR
AU  - Schmidt, Zsuzsanna M.
AU  - Poor, Gyula
PY  - 2022
DA  - 2022/07/27
TI  - Polymyalgia Rheumatica, an Age-Related Rheumatic Disease
JO  - OBM Geriatrics
SP  - 202
VL  - 06
IS  - 03
AB  - Polymyalgia rheumatica (PMR) is an age-related chronic inflammatory disease with rheumatic features at the fore. In addition to the high-grade systemic inflammation, it is characterized by typical “polymyalgic” musculoskeletal symptoms, including diffuse and severe pain and prolonged morning stiffness of the shoulder girdle, pelvic girdle, and neck. PMR is a member of the so-called giant cell arteritis complex; however, in spite of the marked systemic inflammation in PMR, the local vasculitis process aborts. The pathological background is synovitis, with a predominant inflammation of the extra-articular synovial structures. Synovitis of PMR is mild, transient, and non-erosive. Distal musculoskeletal symptoms are also observed but are more variable and less recognizable than the predominant proximal polymyalgic syndrome. PMR often overlaps with elderly-onset seronegative arthritides, elderly-onset rheumatoid arthritis, late-onset seronegative spondylarthritis, and the RS3PE[1] syndrome. Although glucocorticoids are the cornerstone of PMR therapy, considerable hope is attached to tocilizumab, an IL-6 receptor inhibitor.
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.2203202
DO  - 10.21926/obm.geriatr.2203202
ID  - Schmidt2022
ER  -