TY  - JOUR
AU  - Fitzgerald, Ethan
AU  - Kusyk, Dorian
AU  - Tomycz, Nestor D
PY  - 2021
DA  - 2021/04/30
TI  - Deep Brain Stimulation – Therapeutic Possibilities in Alzheimer's Disease
JO  - OBM Geriatrics
SP  - 170
VL  - 05
IS  - 02
AB  - Alzheimer’s Disease (AD) is the leading cause of dementia worldwide, and represents a significant cause of cognitive decline, disability, and mortality. Ongoing clinical trials continue to investigate β-amyloid targeted therapy with unclear benefit, and we are currently limited to symptomatic treatment. Therefore, there is a salient need for the development of novel, potentially disease-modifying therapeutic strategies such as deep brain stimulation. This manuscript reviews Deep Brain Stimulation in Alzheimer’s Disease, describing the pathophysiology of the disease in terms of disordered neural circuitry, and a detailed discussion on trails of stimulation of the fornix, the nucleus basalis of Meynert and the ventral striatum/ventral capsule for the treatment of this dementia.
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.2102170
DO  - 10.21926/obm.geriatr.2102170
ID  - Fitzgerald2021
ER  -