TY  - JOUR
AU  - Brennan, Samuel
AU  - Keon, Matthew
AU  - Su, Zheng
AU  - Liu, Bing
AU  - Song, Xiao Min
AU  - Zaw, Thiri
AU  - McKay, Matthew
AU  - Pascovici, Donna
AU  - Saksena, Nitin K.
PY  - 2021
DA  - 2021/03/29
TI  - Molecular Basis of Allogeneic Pluripotent Stem Cell Treatment of a Patient with Sporadic ALS
JO  - OBM Geriatrics
SP  - 164
VL  - 05
IS  - 01
AB  - There are no curative strategies for ALS, and as a result the alternative therapies are gaining ground, in particular the stem cell-based therapies which hold a promising future. Here we describe an ALS patient, who by choice, received allogeneic human cord-blood derived multipotent stem cells (MSC) intravenously and intrathecally. This is the first snapshot of pre-and post-stem cell transplantation in an ALS patient through transcriptomic, epigenomic, and proteomic follow-up elucidating the effect of stem cells in ALS. Although new CSF proteins (FGA, B2M, FN1 and IGFBP3) were observed, but more work is needed to fully elucidate the effect based on larger cohorts in a clinical trial setting. These analyses may serve as a future guide to both scientists and clinicians alike in defining the utility of such cells in ALS treatment.
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.2101164
DO  - 10.21926/obm.geriatr.2101164
ID  - Brennan2021
ER  -