TY  - JOUR
AU  - D'Arrigo, Joseph
PY  - 2020
DA  - 2020/02/28
TI  - Biomaterial to Improve Drug Delivery in Alzheimer's Disease: Linking Major Pathogenic Pathways
JO  - OBM Geriatrics
SP  - 110
VL  - 04
IS  - 01
AB  - Aging, hypertension, diabetes, obesity, atherosclerosis, traumatic brain injury, and other factors can all synergistically promote diverse pathological mechanisms. These risk factors trigger widespread inflammation and oxidative stress, both of which can lead to blood-brain barrier (BBB) disruption. These pathological cascades lead to neuronal Ca2+ increase, neurodegeneration, gradual cognitive/memory decline, and eventually Alzheimer's disease. In particular, more recent research indicates that chronic inflammatory stimulus in the gut may induce (e.g., via serum amyloid A (SAA)) the release of proinflammatory cytokines. Hence, an effective preventive and therapeutic strategy could be based upon drug targeting toward a major SAA receptor responsible for the SAA-mediated cell signaling events leading to cognitive decline and eventually Alzheimer's disease. In addition, it has already been determined from past studies that drug-carrying lipid nanoparticles can take advantage of physiological receptor-mediated transport processes across the BBB for localized drug delivery in brain tissue.
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.2001110
DO  - 10.21926/obm.geriatr.2001110
ID  - D'Arrigo2020
ER  -