TY  - JOUR
AU  - Ruiz-Mejias, Marcel
AU  - Castano-Prat, Patricia
AU  - Donegan, Tony
AU  - Sanchez-Vives, Maria V.
PY  - 2020
DA  - 2020/02/14
TI  - Cortical Activity and Rhythmic Patterns in Mouse Models of Aging and Alzheimer’s Disease
JO  - OBM Geriatrics
SP  - 105
VL  - 04
IS  - 01
AB  - Aging and Alzheimer’s disease (AD) have been reported to induce changes in the cerebral cortex circuits. The present review aims to study these alterations by reviewing emergent cortical activity with a focus on the rhythmic patterns. The rationale for this approach was two-fold: (i) emergent rhythmic activity integrates cellular and network properties of these underlying circuits; and (ii) alterations in rhythmic patterns reflect the functional impact of changes on the network induced by the pathophysiology of the disease. We first review the changes in cortical circuits that occur with aging and AD in both humans and animal models of early aging (SAMP8) and AD. We provide experimental evidence in support of earlier studies for understanding the cortical synchrony in these neurodegenerative processes, compatible with previous observations in patients with AD. A comparison of experimental findings in the literature opens up a debate in an attempt to understand paradoxical findings in different models when analyzing cortical excitability in AD. Finally, we assess the value of sleep and oscillatory activity in understanding circuit impairments and their roles as biomarkers for AD and neurodegeneration for early intervention.
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.2001105
DO  - 10.21926/obm.geriatr.2001105
ID  - Ruiz-Mejias2020
ER  -