TY  - JOUR
AU  - Wollen, Keith A.
AU  - Hoyt, John W.
PY  - 2019
DA  - 2019/04/18
TI  - Daily Observations of Preserved Cognition and Quality of Life after Multiple Therapies for Postmortem-Verified Severe Alzheimer’s
JO  - OBM Geriatrics
SP  - 048
VL  - 03
IS  - 02
AB  - Abstract
Background: Cognitive abilities in Alzheimer’s Disease are usually examined by formal tests conducted in a laboratory or facility. Such tests are useful for determining the severity of the disease but do not indicate the types of cognition exhibited in the daily lives of patients. This study shows cognitive preservation in daily life by a woman given multiple therapeutic interventions. Since Alzheimer’s disease involves multiple dysfunctions, several studies found multiple therapeutic approaches to be effective in minimizing or even reversing the effects of the disease. The present study included detailed postmortem verification whereas previous studies of multiple therapies have not. 

Methods: The types of cognition displayed in daily living were recorded from the onset of a woman’s symptoms at age 74 to her death 11 years later. Multiple therapies used included prescriptions, supplements, music, exercise, nutrition, extensive social and brain stimulation, and sleep hygiene. Three MRIs and an autopsy were performed.

Results and conclusions: Many types of cognition were observed in the daily life of her final year despite postmortem and MRI findings of severe disease. Possible explanations for this cognitive preservation include multifactor therapies, cognitive/brain reserve, or some combination thereof. The present study revealed several types of cognition that have not been
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.1902048
DO  - 10.21926/obm.geriatr.1902048
ID  - Wollen2019
ER  -