TY  - JOUR
AU  - Liebich, Steve
PY  - 2019
DA  - 2019/04/04
TI  - <b>hTERT Promoter Regulation by Differentiation Mechanisms vs Telomerase Activity in Somatic, Embryonic, and Cancerous Cells</b>
JO  - OBM Geriatrics
SP  - 045
VL  - 03
IS  - 02
AB  - Telomere shortening in the somatic cells is one of the most well-documented factors of cellular ageing. Telomeres are composed of tandem hexanucleotide repeats that protect cells from unwanted recombination mechanisms, secure the ends of chromosomes and their stability, and are responsible for limited division capacity. Telomerase is an enzymatic ribonucleoprotein complex, present in embryonic cells, adult stem cells, and germinal progenitors, whose function is to extend the telomeres length by adding the lost tandem repeats. The main component of the complex and its rate-limiting agent is reverse transcriptase (in humans, hTERT). It has been shown in multiple studies that the differentiated state of the cell corresponds to the cell’s telomerase activity and vice versa. This article discusses a proposal which claims that a strong biomolecular correlation between differentiation factors and the hTERT regulation exists. If to discover what exact mechanisms stay behind this relatedness, the fields of biogerontology, cancer research, and regenerative medicine would highly benefit from the spectacular findings.
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.1902045
DO  - 10.21926/obm.geriatr.1902045
ID  - Liebich2019
ER  -