TY  - JOUR
AU  - Barale, Marco
AU  - Rossetto Giaccherino, Ruth
AU  - Ghigo, Ezio
AU  - Procopio, Massimo
PY  - 2019
DA  - 2019/02/14
TI  - Effect of Six-Months Supplementation with Cholecalciferol on Glycemic and Blood Pressure Control in Elderly Type 2 Diabetic Patients with Vitamin D Deficiency: A Pilot Study
JO  - OBM Geriatrics
SP  - 033
VL  - 03
IS  - 01
AB  - Background: It is well known that hypovitaminosis D has been associated with various cardio-metabolic disorders, though the pathogenetic link, if any, still remains unclear. The aim of our pilot study was to evaluate in uncontrolled non-insulin-treated type 2 diabetic patients with hypovitaminosis D, whether six-month vitamin D supplementation was able to improve glycemic control, lipid profile and blood pressure levels.
Methods: Thirty type 2 diabetic patients (age 71.5±3.2 years, BMI 29.7±3.5 kg/m2) with hypovitaminosis D (25OHvitamin D 22.02±11.31 nmol/l) were randomized to cholecalciferol supplementation (500 UI/kg p.o. weekly, +D) or no intervention (–D) for six months. At baseline, three and six months all patients were evaluated for serum glucose, glycosylated haemoglobin (HbA1c), lipid, systolic (SBP) and diastolic (DBP) blood pressure levels, while calcium mineral metabolism parameters were assessed in all patients at baseline and after vitamin D supplementation.
Results: Vitamin D supplementation had a beneficial effect on fasting glucose (mean percentage changes ± SD, –11.0% ± 19.1 vs +7.4% ± 19.7, respectively; p
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.1901033
DO  - 10.21926/obm.geriatr.1901033
ID  - Barale2019
ER  -