TY  - JOUR
AU  - Szepieniec, Julia
AU  - Dow, Coad Thomas
PY  - 2018
DA  - 2018/11/25
TI  - A is for Autophagy and Alzheimer's
JO  - OBM Geriatrics
SP  - 020
VL  - 02
IS  - 04
AB  - Improved understanding of the underlying cellular dysfunction and resultant neuropathology of sporadic Alzheimer’s disease (AD) is needed to stem the anticipated public health crisis due to this increasingly common neurodegenerative disease. The four main risk factors for sporadic AD are age, female gender, genetic carriage of the APOE4 allele and type two diabetes mellitus (T2DM). Each of these four risk factors is associated with impaired and/or dysfunctional autophagy suggesting that perturbation of autophagy is a root contributor to AD. This article discusses normal cellular autophagy, how each of the AD risk factors impacts autophagy, and currently existing interventions that favorably support the autophagic process.
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.1804020
DO  - 10.21926/obm.geriatr.1804020
ID  - Szepieniec2018
ER  -