OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes a variety of article types (Original Research, Review, Communication, Opinion, Comment, Conference Report, Technical Note, Book Review, etc.). There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.

Publication Speed (median values for papers published in 2023): Submission to First Decision: 5.1 weeks; Submission to Acceptance: 17.0 weeks; Acceptance to Publication: 7 days (1-2 days of FREE language polishing included)

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Special Issue

Third Generation Sequencing

Submission Deadline: January 31, 2019 (Closed) Submit Now

Guest Editor

Milan Macek Jr., MD, DSc

Professor of Medical and Molecular Genetics, Chairman of Department of Biology and Medical Genetics, Chairman of the National Coordination Centre for Rare Diseases, University Hospital Motol and 2nd Faculty of Medicine, Charles University Prague, V Uvalu 84, Praha 5, CZ 150 06, Czech Republic

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Research Interests: molecular genetics; human genetics; medical genomics; reproductive genetics; rare diseases; cystic fibrosis; health economics

Guest Editors

Third generation sequencing (also known as long-read sequencing, TGS) is a class of DNA sequencing methods, which is creating a renaissance in high-quality genome sequencing. By enabling direct sequencing of single DNA molecules, TGS has the capability to produce substantially longer reads, in contrast to second generation sequencing, which produces short reads a few hundred base-pairs long. TGS, as it currently stands, faces important challenges mainly surrounding accurate identification of nucleotide bases which lead to higher error rates than second generation sequencing, rendering the technologies impractical for certain applications such as de novo genome assembly. These technologies are undergoing active development and therefore it is expected that there will be further improvements to reduce the high error rates. For applications that are more tolerant to error rates, TGS has been found to outperform existing methods.

In this special issue of OBM Genetics, we aim to the introduction of current technologies, application as well as many challenges and limitations TGS faces. We accept original research papers, reviews, editorial, short communications, case reports and perspectives on TGS. We sincerely welcome authors in this field to contribute their excellent works to this exciting forum.

Manuscript Submission Information

Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (genetics@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.

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