(ISSN 2577-5790)
OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes a variety of article types (Original Research, Review, Communication, Opinion, Comment, Conference Report, Technical Note, Book Review, etc.). There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
Publication Speed (median values for papers published in 2023): Submission to First Decision: 5.1 weeks; Submission to Acceptance: 17.0 weeks; Acceptance to Publication: 7 days (1-2 days of FREE language polishing included)
Special Issue
Ovarian Development and Differentiation
Submission Deadline: December 31, 2018 (Closed) Submit Now
Guest Editor
Sergei G. Tevosian, PhD
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32612, USA
Research Interests: reproductive genetics; developmental genetics; adrenal development; developmental biology
About This Topic
The beginning of this century saw an unprecedented leap in our understanding of the mechanisms guiding mammalian female sexual determination as well as development, differentiation and function of the mammalian ovary. When an amazing flurry of research papers during that time were reviewed just six years ago, it appeared that a progress in this field would be worth revisiting on a yearly basis. Unfortunately, these predictions were based merely on the extraordinary advancement of research and the scientific merit of the discoveries. Fundamental science requires substantial financial support that notably decreased during the present decade, at least in the United States. However, despite these difficult times, even at a slower pace, many important developments enhanced our knowledge of ovarian differentiation and provided new important concepts and insight that, we feel, is now worth revisiting and appraising.
This issue of OBM Genetics attempts to integrate the recent work on the differentiation of the mammalian ovary. The major function of the ovary is the organization and coordination of the female germ cell differentiation. During fetal development, female germ cells switch from proliferation to meiosis before forming follicles. In the adult, the ovary stores and releases mature oocytes into the oviduct. We intend to cover a wide variety of topics including granulosa cell proliferation and survival, meiotic progression, follicle formation, assembly and growth, ovarian vascularization, steroid hormone production, and corpora luteal function. We will also review recent progress in understanding the contribution of epigenetic mechanisms to ovarian cell differentiation. Epigenetic mechanisms are important since gametes and developing embryos are sensitive to environmental factors during the critical period of gamete reprogramming. Adverse epigenetic modifications could have harmful impact on pregnancy outcomes and health of the offspring, and can be inherited over several generations. Genetic and epigenetic disorders in the somatic or germ cell development can result in abnormal folliculogenesis, reduced fertility and primary ovarian insufficiency.
Manuscript Submission Information
Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (genetics@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.
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Publication
Disturbed Ovarian Differentiation in XX;SRY-Negative DogsAbstract In a mammal, at the beginning of its development, the gonad is bipotential. The shift into a male or female pathway is coordinated by the sex chromosomal complement, which triggers a series of genetic pathways signaling the developmental pattern of the gonadal anlage. Being mutually exclusive, the differentiated gonad should be either a testis [...] |
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Zhong-Ting (Justin) is a PhD student from Nanyang Technological University (Singapore). He holds BSc in Applied Chemistry and MSc in Environmental Engineering. He was a R&D researcher of NanoMaterials Technology Pte Ltd in Singapore (2006-2012). His current research interests are functional nanomaterials synthesis & design, and their application into environmental/chemical engineering. He has published near 60 SCI papers in Applied Catalysis B, Chemical Engineering Journal and so on with H-Index 23. He also serviced as reviewers over 40 Journals such as Appl. Catal. B, Water Research, Chem. Eng. J, ACS Applied Materials & Interface, etc. He was honored such as “The Bsic Research Achievment 1st Award of CIESC”, “The ZJUT Fund Breeding Distinguished Young Scholars” etc.
Rolf Teschke studied Medicine in Munich and Marburg, where he finished his MD thesis before starting a residency at the Department of Pathology, University of Marburg. Subsequently and with a fellowship of the Deutsche Forschungsgmeinschaft, he worked at the Bronx VA Hospital/Mount Sinai Hospital in New York during 1972–1975 together with Professor Charles S. Lieber and successfully isolated MEOS and expanded its characterization. Back in Germany, he was at the Heinrich-Heine University in Düsseldorf with a focus on alcoholic liver disease, biochemical drug studies, and clinical intoxications by halogenated aliphatic hydrocarbons, where he became a Professor of Medicine. In 1987, he was offered a chief position and appointed as Director of the Medical Department II, City Hospital Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt/Main. His clinical and research interests are on liver injury by drugs and herbs including causality assessment by RUCAM in close association with Dr. Gaby Danan in Paris. A perfect cooperation exists also with Professor Tran Dang Xuan of the University of Hiroshima, Japan. Finally, he is the author of more than 275 publications including books and book chapters, and he is editor in chief of scientific journals and member of editorial boards.