TY  - JOUR
AU  - Hameed, Samaa Asaad
AU  - Banimusleum, Thikra Adnan Jawad
AU  - Jameel, Zahraa Isam
PY  - 2026
DA  - 2026/09/28
TI  - <i>IL-6</i> rs1800796 Genotype Variants Among Iraqi Patients Suffering from Sepsis
JO  - OBM Genetics
SP  - 360
VL  - 10
IS  - 03
AB  - Sepsis has a complex genetic background; many genes may directly or indirectly affects its development. Since cytokines control the type, severity, and consequences of pathogenesis, they are also involved in some aspects of sepsis. This research aims to investigate the relationship between IL-6 gene polymorphism and sepsis. For this research, a total of 75 patients with sepsis disease and another 75 individuals without the disease were taken as the controls for this genetic study. The IL-6 gene has many high-frequency polymorphisms; these polymorphisms were amplified using well-chosen primers. In the serum of individuals with sepsis (240.42 ± 84.25 pg/mL), IL-6 was found to be higher compared to the control group (203.58 ± 22.47 pg/mL). Finally, the rs1800796 polymorphism is correlated with the risk of developing sepsis, with the G/A heterozygous variation providing a high level of risk under the dominant inheritance model of the polymorphism. There is no relationship with the recessive model, suggesting that the presence of the GA genotype and the dominant model (GA + AA) had significantly higher chances of sepsis compared with other genotypes (OR = 4.05 and 3.00, respectively; p < 0.05). The findings show a clear link between the genetic variation of the IL-6 gene and the regulation of IL-6 during sepsis.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2603360
DO  - 10.21926/obm.genet.2603360
ID  - Hameed2026
ER  -