TY  - JOUR
AU  - Rawal, Leena
AU  - Thamtam, Vamshi Krishna
PY  - 2026
DA  - 2026/08/10
TI  - Jumping Translocation of Chromosome 11q in <i>De Novo</i> Acute Myeloid Leukemia: A Rare Chromosomal Aberration
JO  - OBM Genetics
SP  - 351
VL  - 10
IS  - 03
AB  - Acute myeloid leukemia (AML) represents a clinically and genetically heterogeneous group of hematologic malignancies. Among the less frequently encountered cytogenetic abnormalities are jumping translocations (JTs), in which a segment from a donor chromosome relocates to multiple recipient chromosomes. Although uncommon, these events have been described in association with clonal evolution and, in some cases, more aggressive disease behavior. Here, we describe a 49-year-old man who presented with fatigue and generalized weakness and was subsequently diagnosed with AML harboring an inv(16)(p13.1q22)/CBFB::MYH11 rearrangement. In addition to the primary leukemic clone, cytogenetic evaluation identified three sideline clones demonstrating a jumping translocation involving chromosome 11 with the breakpoint at band 11q13. The 11q13 segment was observed on different recipient chromosomes, namely 16p13.1, 19p13.3, and 21q22, indicating a notable degree of clonal heterogeneity. While AML with inv(16) is typically associated with a favorable prognosis, the concurrent presence of a chromosome 11q13 jumping translocation in this case suggests added biological complexity. Such secondary cytogenetic changes may have implications for disease evolution and risk stratification. This case underscores the importance of integrating conventional cytogenetic analysis with next-generation sequencing to delineate clonal architecture better and support clinical decision-making in AML.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2603351
DO  - 10.21926/obm.genet.2603351
ID  - Rawal2026
ER  -