TY  - JOUR
AU  - Eyüpoğlu, Havva Özgen
AU  - Çağsın, Hüseyin
AU  - Serakıncı, Nedime
PY  - 2026
DA  - 2026/05/13
TI  - Latest Approaches in Cancer Therapy and Remaining Gaps
JO  - OBM Genetics
SP  - 339
VL  - 10
IS  - 02
AB  - Cancer remains one of the major global challenges due to its complex and heterogeneous molecular nature across individuals. Recent advances in technology have enhanced the understanding of cancer’s molecular mechanisms, paving the way for the development of effective therapeutics. These include small-molecule inhibitors and monoclonal antibodies, used to interfere with the oncogenic signaling pathways. Immunotherapy has also emerged as a promising area in cancer therapy, with approaches such as immune checkpoint inhibitors, immune cell engagers, adoptive T-cell therapies, and cancer vaccines. Besides, stem cell-based approaches are also being assessed for their potential to modulate immune responses and promote tissue repair. Although these advances have improved cancer care, significant challenges remain. The major challenges in cancer therapy may include drug resistance, side effects, and systemic toxicity that diminish therapeutic efficacy. Moreover, the heterogeneous nature of tumors and the immunosuppressive tumor microenvironment (TME) in solid tumors further complicate treatment responses, especially in advanced or aggressive cancers. Hence, in this review, we highlight the latest approaches in cancer therapy and discuss the remaining gaps and challenges that hinder their full clinical potential.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2602339
DO  - 10.21926/obm.genet.2602339
ID  - Eyüpoğlu2026
ER  -