TY  - JOUR
AU  - Uddin, Taslim
AU  - Zohora, Fatema Tuz
AU  - Khanam, Tajmin
AU  - Akter, Moumita
AU  - Himika, Lubaba Ibnul
AU  - Aziz, Anika Tabassum
AU  - Tabassum, Fariha
AU  - Tushy, Syeda Marjia Kajol
AU  - Aktar, Salaha
AU  - Misha, Maisha Maliha
AU  - Nimu, Shaikh Nuzhat Nawshin
AU  - Tasnim, Sadia
AU  - Joya, Shammi Akter
AU  - Mahisa, Israt Tasnim
AU  - Pinky, Shahrin Akter
PY  - 2026
DA  - 2026/04/15
TI  - Climate Change-Induced Stress and Neural Plasticity: Genetic and Epigenetic Mechanisms of Adaptation
JO  - OBM Genetics
SP  - 337
VL  - 10
IS  - 02
AB  - Changes in the environment driven by climate change are becoming significant stressors that impact brain function, but the connections between these changes and neural plasticity remain unclear. This review aims to offer a comprehensive synthesis of the impact of climate-related stressors on neural plasticity via genetic and epigenetic mechanisms. A structured literature search (2000-2025) was conducted using PubMed, Scopus, and Web of Science, integrating evidence from in vitro, animal, and human studies. Findings indicate that stressors such as heat, pollution, psychosocial adversity, and hypoxia alter neural plasticity through interconnected pathways, such as oxidative stress responses, mitochondrial adaptation, neurotrophic signaling, and epigenetic regulation. The strength of evidence varies; mechanistic insights are primarily obtained from experimental models, whereas human data are mostly associative. We propose a framework for an adaptive-maladaptive continuum based on the intensity, duration, and timing of stressors in development. Overall, this review highlights key knowledge gaps and provides a structured roadmap to improve causal inference and translational relevance.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2602337
DO  - 10.21926/obm.genet.2602337
ID  - Uddin2026
ER  -