TY  - JOUR
AU  - Silvestre, Rafaele Tavares
AU  - Chantre-Justino, Mariana
AU  - Bragante, Mariana Alexandre
AU  - de Carvalho, Paula Lacorte
AU  - Delmonico, Lucas
AU  - Alves, Gilda
AU  - Ornellas, Maria Helena
AU  - de Lima, Dirce Bonfim
PY  - 2026
DA  - 2026/02/04
TI  - Analysis of Leukocyte Telomere Length in Brazilian People Living with HIV with and Without Cancer
JO  - OBM Genetics
SP  - 326
VL  - 10
IS  - 01
AB  - Advances in antiretroviral therapy (ART) have normalized the life expectancy of people living with HIV (PLWH) but have been linked to a premature presentation of age-related comorbidities, including cancer. Telomere length (TL) is a marker of cellular aging and was investigated in blood leukocytes from 78 PLWH on ART, compared with 163 HIV-uninfected controls. The PLWH group was stratified into three subgroups: HIV-only (n = 57), HIV with AIDS-defining cancer (ADC, n = 9), and HIV with NADC (n = 12). Quantitative polymerase chain reaction (qPCR) was used to measure the Relative Telomere Length (RTL), expressed as a T/S ratio. The mean RTL was significantly longer in PLWH (p = 0.0002) and in the HIV/Cancer group (p = 0.0125) than in the control group (n = 163). In addition, the mean RTL was significantly longer in the PLWH group with non-AIDS-defining cancers (NADCs) compared to the control group (p = 0.03). However, no statistical difference between the HIV-only versus the HIV/cancer groups concerning RTL was observed. PLWH with a longer time since diagnosis of HIV infection (>13 years) had a trend towards longer RTL, showing a borderline statistical significance (p = 0.06). Analysis by cancer type showed ADCs were mainly Kaposi’s sarcoma (44.5%) and cervical cancer (33.3%), while NADCs were most commonly anal cancer (25%) and breast cancer (16.7%). These findings support the thesis that long-term ART may be associated with telomere elongation in PLWH, challenging the general perception of telomere shortening in this population. The significantly longer RTL in the NADC group suggests that telomere elongation confers greater cellular replicative potential, which might contribute to the elevated cancer risk in PLWH.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2601326
DO  - 10.21926/obm.genet.2601326
ID  - Silvestre2026
ER  -