TY  - JOUR
AU  - Agiannitopoulos, Konstantinos
AU  - Kouvidi, Elisavet
PY  - 2025
DA  - 2025/12/25
TI  - The Application of Next-Generation Sequencing in Leukemia
JO  - OBM Genetics
SP  - 321
VL  - 09
IS  - 04
AB  - Leukemia is a heterogeneous group of hematologic malignancies characterized by the dysfunctional proliferation of white blood cells in the bone marrow. Genetic alterations are important risk factors for the development and progression of leukemia, and their detection is crucial. Although many genetic techniques, including karyotyping, fluorescence in situ hybridization (FISH), and polymerase chain reaction (PCR), have provided valuable information, they all have the limitation of incomplete genomic coverage. The evolution of genomic technologies, including Next Generation Sequencing (NGS) and Third Generation Sequencing (TGS), has enabled a more comprehensive and detailed characterization of the genetic landscape of leukemia. NGS technology has revolutionized leukemia diagnosis, treatment, and minimal residual disease monitoring, and its integration into routine leukemia care will enhance patient outcomes and pave the way for truly personalized medicine.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2504321
DO  - 10.21926/obm.genet.2504321
ID  - Agiannitopoulos2025
ER  -