TY  - JOUR
AU  - Kostek, Matthew
AU  - Liu, Siyu
PY  - 2023
DA  - 2023/09/19
TI  - Normal and Aberrant Muscle Tissue Healing, Learning from Health and Disease
JO  - OBM Genetics
SP  - 192
VL  - 07
IS  - 03
AB  - Human skeletal muscle exhibits remarkable plasticity, being responsive to chemical, mechanical, metabolic, and inflammatory stress. When the homeostatic disturbance is below a threshold of significant damage, the muscle responds by modifying metabolic activity, cell size/shape, and structure, thereby normalizing cellular function. If the disturbance causes significant damage, skeletal muscle, along with a precisely choreographed response from the immune system, can regenerate. Very few pathological conditions inhibit these adaptive responses in muscle. Yet, from these few conditions, we can learn a great deal. Working with the immune system, normal muscle healing can inform disease treatments, and the disease pathology informs our understanding of normal muscle healing. Here we use Duchenne Muscular Dystrophy (DMD) as a model of failed muscle adaptation/regeneration to attempt to understand normal muscle healing, why it sometimes fails, and how normal muscle response might be applied to understand and treat DMD.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2303192
DO  - 10.21926/obm.genet.2303192
ID  - Kostek2023
ER  -