TY  - JOUR
AU  - Parveen, Sana
AU  - Rizvi, Suroor Fatima
AU  - Hasan, Adria
AU  - Afaq, Uzma
AU  - Mir, Snober Shabnam
PY  - 2022
DA  - 2022/11/08
TI  - Novel Insights into Epigenetic Control of Autophagy in Cancer
JO  - OBM Genetics
SP  - 170
VL  - 06
IS  - 04
AB  - The autophagy mechanism recycles the damaged and long-standing macromolecular substrates and thus maintains cellular homeostatic and proteostatic conditions. Autophagy can be an unavoidable target in cancer therapy because its deregulation leads to cancer formation and progression. Cancer can be controlled by regulating autophagy at different genetic, epigenetic, and post-translational levels. Epigenetics refers to the heritable phenotypic changes that affect gene activity without changing the sequence. Modern biology employs epigenetic alterations as molecular tools to detect and treat a wide range of disorders, including cancer. However, modulating autophagy at the epigenetic level may inhibit cancer growth and progression. Epigenetics-targeting drugs involved in preclinical and clinical trials may trigger antitumor immunity. Here, we have reviewed some experimental evidence in which epigenetics have been used to control deregulated autophagy in cancerous diseases. Furthermore, we also reviewed some current clinical trials of epigenetic therapy against cancer. We hope that this information can be utilized in the near future to treat and overcome cancer.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2204170
DO  - 10.21926/obm.genet.2204170
ID  - Parveen2022
ER  -