TY  - JOUR
AU  - Udina, Irina
AU  - Vasiliev, Yurii
AU  - Volobuyev, Vladimir
AU  - Gulenko, Olga
AU  - Gracheva, Alesya
PY  - 2022
DA  - 2022/06/27
TI  - Molecular Genetic Study on VNTR-polymorphism of Two Cytokine Genes Antagonist of the Receptor of Interleukin 1 (rs2234663) and Interleukin 4 (rs8179190) Associated with Dental Caries in Children
JO  - OBM Genetics
SP  - 158
VL  - 06
IS  - 02
AB  - In this study, we investigated VNTR polymorphisms in intron 2 of the IL1RN gene (rs2234663) and intron 3 of the IL4 gene (rs8179190) related to the development of caries in school children (N = 196) with mixed bite dentition from Krasnodarskii Krai. The genotypes A1/A1 and L/L (L-“long” alleles) (rs2234663) provided resistance to the most intensive form of dental caries. The groups of children with DFC (decompensated form of caries) were significantly different from the pooled group SFC (subcompensated form of caries) and CFC (compensated form of caries) (and healthy children) for two genotypes: A1/A1 (OR = 0.37, p = 0.015, 95% CI: 0.17-0.84) and L/L (OR = 0.38. p = 0.020, 95% CI: 0.17-0.88). In locus rs8179190 (IL4), a rare allele with a single repeat (70 bp)-P3 (113 bp) was observed. For VNTR polymorphisms of rs8179190, association with the most intensive form of caries was found only for two-locus genotypes with rs2234663. The results suggested that the studied cytokine markers and the ratio of the pro-inflammatory to anti-inflammatory cytokines might be involved in the development of the most intensive form of caries.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2202158
DO  - 10.21926/obm.genet.2202158
ID  - Udina2022
ER  -