Table of Contents

Open Access

ISSN 2577-5790

OBM Genetics , Volume 6 , Issue 1 (2022)

Pages: 92

Published: April 2022

(This book is a printed edition that was published in OBM Genetics)

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Cover Story:In our study, we elucidated the correlations of mutational signatures in frequently mutated cancer genes with general mutational signatures previously found for different cancers. By finding which genes have high correlations with certain general signatures, we may be able to determine clearer relations between the mutated genes and specific cancer types.View this paper.

Volume 6,Issue 1

Open Access Review

Molecular Marker Analysis of Genetic Diversity in Maize: A Review

Received: 25 July 2021;  Published: 21 March 2022;  doi: 10.21926/obm.genet.2201150


Maize is consumed as a food and used as an industrial product in the form of starch, pharmaceuticals, alcoholic beverages, oil, cosmetics, and textiles. In ancient times, landraces were more popular due to the presence of high genetic variability, resistance to biotic and abiotic factors, and the heterogeneous nature of maize; however, it has been replaced by improved and uniform cultivars with a higher yield. Modern maize has more homogeneity that enhances its vulnerability to biotic and abioti [...]

Open Access Original Research

The Regulation of Non-Invasive Prenatal Testing (NIPT) in France: Continuity and Changes in the Development of Prenatal Testing

Received: 02 September 2021;  Published: 25 February 2022;  doi: 10.21926/obm.genet.2201149


This article examines the regulation of the screening of fetal abnormalities in France before and after the implementation of the new technique of non-invasive prenatal testing (NIPT) in 2013. In addition, this article evaluates the effectiveness of the regulatory framework in addressing the ethical and social issues raised by this technique from a legal and sociological perspective. The analysis reveals that the regulations, consistent with that applied to other prenatal screening techniques, f [...]

Open Access Interview

An Interview with Dr. Joep Geraedts

Received: 17 February 2022;  Published: 22 February 2022;  doi: 10.21926/obm.genet.2201148

Open Access Research Article

Correlation of Mutational Signatures in Cancer Genes with General Signatures

Received: 07 December 2021;  Published: 13 February 2022;  doi: 10.21926/obm.genet.2201147


The occurrence of various mutation patterns, such as changes in the DNA sequence and the loss of some sequences, is called a “mutational signature,” and they represent the molecular fingerprints that exist for the type of mutation occurring in a specific gene. Our study elucidates the correlations of mutational signatures in frequently mutated cancer genes with general mutational signatures previously found for different cancers. We hypothesized that the top twenty most frequently mu [...]

Open Access Short Communication

Newborn Screening in Latin America: A Window on the Evolution of Health Policy

Received: 22 August 2021;  Published: 21 January 2022;  doi: 10.21926/obm.genet.2201146


Investigating the historical origins of a well-accepted health program across a region, such as newborn screening in Latin America, has the potential to reveal the role of historically-specific drivers in shaping national health policy. We reviewed published reports on NBS in Latin America and interviewed newborn screening experts with experience in the region. We found trends suggesting that the decrease in infant mortality may be a prerequisite to investing in nationwide screening [...]

Open Access Review

Anatomical Variation, Hominins, Species, and Self-Domestication

Received: 19 October 2021;  Published: 11 January 2022;  doi: 10.21926/obm.genet.2201145


The evolution of hominins, members of the zoological tribe Hominini, has been a much-studied topic, and the construction of phylogenetic trees has been the key method in molecular evolutionary studies. How scientists determine the phylogenetic trees are governed by the assumptions they place on the construction of similarities and differences in morphological traits, the differences in the number of base pairs in the genomes, and the number of similar gene clusters that code for trai [...]

Open Access Editorial

Acknowledgement to Reviewers of OBM Genetics in 2021

Received: 05 January 2022;  Published: 06 January 2022;  doi: 10.21926/obm.genet.2201144


The editors of OBM Genetics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2021. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate o [...]