TY  - JOUR
AU  - O’Sullivan, Sean J.
PY  - 2021
DA  - 2021/11/17
TI  - Understanding the Regulation of Transcription in Mental Illness
JO  - OBM Genetics
SP  - 143
VL  - 05
IS  - 04
AB  - Advances in clinical psychiatry have been less than hoped for relative to the achievements in neuroscience. However, developments in neuromodulation and psychedelic therapy are promising. The efficacy of such treatments and canonical pharmacotherapies benefit from genetics and personalized medicine. Moreover, recent studies on the perturbation of transcription, including chromatin remodeling, in mental illness emphasized the importance of single-cell qPCR as an investigatory method that  bolstered psychiatry. This technique demonstrated chromatin remodeling as a biomarker for addiction and the underlying mechanism of depression. If personalized medicine, along with canonical and newer therapies, can mediate and regulate transcription, epidemics in depression and addiction can be mitigated. This motivates investigators to continue to use single-cell transcription measures in models of mental illness for translational medicine.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2104143
DO  - 10.21926/obm.genet.2104143
ID  - O’Sullivan2021
ER  -