TY  - JOUR
AU  - GOLDING, Jean
AU  - Clark, Rosie
AU  - Gregory, Steven
AU  - Ellis, Genette
AU  - Suderman, Matthew
AU  - Iles-Caven, Yasmin
AU  - Pembrey, Marcus
PY  - 2021
DA  - 2021/10/29
TI  - Unexpected Associations between the Number of FRAXE Repeats in Boys and Evidence of Diabetes in Their Mothers and Maternal Grandmothers
JO  - OBM Genetics
SP  - 141
VL  - 05
IS  - 04
AB  - The FRAXE section of the FMR2 gene, located on the X chromosome, contains varying numbers of trinucleotide repeats; boys with over 200 repeats tend to have mild cognitive impairments, though this is rare. Little is known, however, concerning the phenotypes of individuals with smaller numbers of repeats. Here we answer the research question as to whether the health of ancestors of boys from whom the relevant X chromosome was inherited differed in any way according to the number of FRAXE repeats. Numbers of FRAXE repeats in 5057 boys from the Avon Longitudinal Study of Parents and Children (ALSPAC) were assessed. The distribution was bimodal, with the second smaller distribution starting at 22 repeats. We tested whether possession of 22+ repeats was associated with differences in the health of mothers (who share the X chromosome) and maternal grandmothers (half of whom share it). Female ancestors of boys with >21 repeats compared with 
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2104141
DO  - 10.21926/obm.genet.2104141
ID  - GOLDING2021
ER  -