TY  - JOUR
AU  - Privalle, Laura
AU  - Back, Patricia
AU  - Bhargava, Apurv
AU  - Bishop, Zach
AU  - Cisneros, Krystal
AU  - Coats, Isabelle
AU  - Criel, Ine
AU  - Dhondt, Lien
AU  - Draughn, Travis
AU  - Fowler, Barb
AU  - Franklin, Brad
AU  - Ghoshal, Durba
AU  - Lor, Jim
AU  - Massengil, Jennifer
AU  - Moens, Sofie
AU  - Mooney, Tyson
AU  - Nelson, Dannyel
AU  - Peeters, Karolien
AU  - Sathischyandra, Sashi
AU  - Staut, Caroline
AU  - Sung, Yoonhui
AU  - Tuttle, Ann
AU  - Van Hoecke, Annelies
AU  - Van Raemdonck, Annelies
AU  - Verdegem, Marie-Laure
AU  - Verhaeghe, Steven
AU  - Walsh, Shane
AU  - Wierckx, Ann
AU  - Zhao, Qiang
AU  - Dreesen, Rozemarijn
PY  - 2020
DA  - 2020/12/02
TI  - Genetic Stability, Inheritance Patterns and Expression Stability in Biotech Crops
JO  - OBM Genetics
SP  - 120
VL  - 04
IS  - 04
AB  - Demonstration of the stability of traits newly introduced into a plant genome via genetic engineering approaches comprise a significant portion of the safety assessment that these products undergo prior to receiving the requisite regulatory approvals enabling commercial authorization. Different regions of the world have different regulatory requirements and many ask similar questions from multiple and overlapping perspectives. The entire central dogma, that is stability at the DNA level, mRNA level and protein level, is assessed for each product, although only a few regulatory authorities request data at the mRNA level. In this article, we present inheritance data obtained during the safety assessment of biotech products representing specific transgenic events in several crop species including Brassica napus (canola); canola quality Brassica juncea (yellow seeded canola); Glycine max (soybean), and Gossypium hirsutum (cotton) in which different traits have been introduced. The data presented confirm that all events examined were nuclear insertions that resulted in typical Mendelian Inheritance patterns and that the proteins are expressed similarly across multiple generations regardless of whether they were from backcrossed or outcrossed generations. These results demonstrate that newly inserted genes are transmitted to their progeny in a stable manner similar to that of endogenous genes. Further, the findings demonstrate that assessments of multigenerational stability have very limited value to a safety assessment.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2004120
DO  - 10.21926/obm.genet.2004120
ID  - Privalle2020
ER  -