TY  - JOUR
AU  - Park, Joun
AU  - Tao, Xianzun
AU  - Zhai, R. Grace
PY  - 2020
DA  - 2020/03/20
TI  - Knight in Splicing Armor: Alternative Splicing as a Neuroprotective Mechanism
JO  - OBM Genetics
SP  - 106
VL  - 04
IS  - 01
AB  - By adjusting gene expression in response to environmental changes, cells can optimize fitness as needed. Alternative splicing is one of the most important post-transcriptional regulation steps, broadly involved in diverse physiological and pathological conditions. Here, we present 5 cases of alternative splicing conferring increased neuroprotection through diverse mechanisms. These examples highlight the enormous power of alternative splicing in maintaining viability of neurons. From pre-mRNA secondary structure alterations to exon skipping and alternative splice sites, we describe how various mechanisms can be utilized in a functionally significant manner. While these instances focus on endogenous splicing control, it highlights the therapeutic potential of modifying these genes. With the urgency for neurodegenerative disease intervention rising, these targets represent excellent targets to focus on.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2001106
DO  - 10.21926/obm.genet.2001106
ID  - Park2020
ER  -