TY  - JOUR
AU  - Chang, Kwang Poo
AU  - Ng, Dennis KP
AU  - Fan, Chia-Kwung
AU  - Batchu, Ramesh B.
AU  - Kolli, Bala K
PY  - 2020
DA  - 2020/02/24
TI  - Effective Delivery of Cancer Vaccines with Oxidatively Photo-Inactivated Transgenic Leishmania for Tumor Immunotherapy in Mouse Models
JO  - OBM Genetics
SP  - 103
VL  - 04
IS  - 01
AB  - The parasitic protozoa in the genus of Leishmania have exceptionally favorable attributes for exploitation as a vehicle for safe and effective delivery of transgenically incorporated vaccines against infectious and malignant diseases. A dual suicidal mechanism was installed in Leishmania via genetic and chemical engineering in vitro for accumulation of photosensitizers, rendering them sensitive to dim light for inactivation. Leishmania so inactivated are non-viable, but immunologically competent to deliver vaccines for immune-prophylaxis and –therapy. We have begun to explore the utility of these Leishmania for immunization against tumors in experimental mouse models.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.2001103
DO  - 10.21926/obm.genet.2001103
ID  - Chang2020
ER  -