TY  - JOUR
AU  - Kakourou, Georgia
AU  - Mamas, Thalia
AU  - Vrettou, Christina
AU  - Traeger-Synodinos, Jan
PY  - 2019
DA  - 2019/07/22
TI  - Preimplantation Genetic Testing for HLA-matching: An Overview of Clinical Application and Utility
JO  - OBM Genetics
SP  - 084
VL  - 03
IS  - 03
AB  - Preimplantation Genetic Testing for HLA-matching (PGT-HLA) has been one of the most controversial PGT applications, first reported in 2001. The procedure aims to identify an embryo that is not only healthy but also HLA-matched with a sibling in the family in need of haematopoietic stem cell transplantation (HSCT), considering that sibling HSCT stands the highest chance of success in comparison to alternative approaches. HLA-typing can be performed with or without PGT-M for the exclusion of a single-gene disorder. The diagnostic PGT approach has greatly evolved over the years. HLA haplotyping by linkage analysis has been the most applied generic approach to date, but newer techniques (SNP arrays, NGS) have been applied recently. PGT-HLA is a complex procedure that must be very well orchestrated between specialists of many different disciplines to ensure that successful HSCT is completed on time. This review discusses the PGT procedure and methodology, PGT-HLA clinical application and utility and underlines how, despite the limitations, it has been a successful and realistic approach for many couples.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.1903084
DO  - 10.21926/obm.genet.1903084
ID  - Kakourou2019
ER  -