TY  - JOUR
AU  - Ellmann, Anna
AU  - Schmidt, Manfred
AU  - Fietkau, Rainer
AU  - Distel, Luitpold
AU  - Schuster, Barbara
AU  - Mayo, Theresa
PY  - 2019
DA  - 2019/06/26
TI  - Individual Radiosensitivity in Lung Cancer Patients Assessed by G0 and Three Color Fluorescence <i>in Situ</i> Hybridization
JO  - OBM Genetics
SP  - 082
VL  - 03
IS  - 02
AB  - Background: It is known that radiosensitivity is very individual. This can influence the tumor response and side effects in normal tissue after radiotherapy of cancer. Therefore we analyzed the sensitivity of a lung cancer cohort to see if they display a similar radiosensitivity distribution if compared to a healthy individuals and a rectal cancer patients cohort.
Methods: Blood samples of 282 individuals were irradiated ex vivo and chromosomes # 1, 2 and 4 were stained by the 3-color fluorescence in situ hybridization. Additionally we analyzed data from 400 partly previous published individuals. Chromosomal aberrations were counted and expressed via breaks per metaphase (B/M). The background chromosomal aberrations were subtracted to obtain solely the radiation induced aberrations.
Results: The lung cancer cohort has significantly increased background B/M values (p
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.1902082
DO  - 10.21926/obm.genet.1902082
ID  - Ellmann2019
ER  -