TY  - JOUR
AU  - De Paepe, Boel
PY  - 2019
DA  - 2019/05/16
TI  - The Changed Transcriptome of Muscular Dystrophy and Inflammatory Myopathy: Contributions of Non-Coding RNAs to Muscle Damage and Recovery
JO  - OBM Genetics
SP  - 079
VL  - 03
IS  - 02
AB  - In order to successfully recover from damage, skeletal muscle tissue requires proper activation of a tightly orchestrated repair program. To this complex process of demolition and rebuilding, non-coding RNAs actively participate. In this review, the contribution of dysregulated non-coding RNA expression to disease-associated pathological changes is explored in the hereditary muscular dystrophies and the idiopathic inflammatory myopathies. Disturbances in spatiotemporal expression of non-coding RNAs appear key factors to disease progression, functioning both in favor of and opposed to recovery. They regulate regeneration and survival of muscle fibers, and codetermine severity of tissue fibrosis and inflammation. Non-coding RNAs display individual or pleiotropic effects, and strongly influence each other’s activities. The described altered expression patterns can be exploited as biomarkers for diagnosis and to evaluate therapeutic success. In addition, common signatures often present in different muscle disorders points to their manipulation as an approach with potentially broader therapeutic use.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.1902079
DO  - 10.21926/obm.genet.1902079
ID  - De Paepe2019
ER  -