TY  - JOUR
AU  - Hayakawa, Koji
AU  - Shiota, Kunio
AU  - Tanaka, Satoshi
AU  - Hirosawa, Mitsuko
PY  - 2018
DA  - 2018/09/17
TI  - Histone O-GlcNAcylation and Potential Biological Functions
JO  - OBM Genetics
SP  - 036
VL  - 02
IS  - 03
AB  - Histone modifications play an important role in the control of DNA-based processes by altering the structure and function of chromatin. O-linked N-acetylglucosamine (O-GlcNAc) modification is a form of post-translational modification of proteins that affects the serine (Ser)/threonine (Thr) residues. This process is controlled by a single pair of enzymes, i.e. O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Recent evidence indicates the existence of O-GlcNAc modification of histones, with 16 histone O-GlcNAc sites reported to date. O-GlcNAc modification is a nutrient-sensitive modification; therefore, it is likely to serve as a molecular mechanism linking nutrient conditions and epigenetic status. Recently, functional analyses have been advanced by the acquisition of antibodies for the specific detection of O-GlcNAcylation of histone residues. Here, we discuss the current knowledge of histone O-GlcNAc modification, with a view to elucidating its comprehensive biological functions.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.1803036
DO  - 10.21926/obm.genet.1803036
ID  - Hayakawa2018
ER  -