TY  - JOUR
AU  - Bakloushinskaya, Irina
AU  - Matveevsky, Sergey
PY  - 2018
DA  - 2018/07/22
TI  - Unusual Ways to Lose a Y Chromosome and Survive with Changed Autosomes: a Story of Mole Voles <i>Ellobius</i> (Mammalia, Rodentia)
JO  - OBM Genetics
SP  - 023
VL  - 02
IS  - 03
AB  - Species of mole voles Ellobius demonstrate a broad variation in sex chromosomes and autosomes, which is unique among mammals. In four species, a Y chromosome was lost, and X0 or XX sex chromosomes in both sexes were obtained. The key testis-determining Sry (Sex-determining Region on Y) gene is absent in these species, and the regulation of its target, the Sox9 (SRY -box 9) gene, is questionable due to deletion in the key enhancer. In a single species, E. fuscocapillus, with routine XX-XY, the same deletion is present alongside fragments of Sry in the female genome. Presumably, a Y chromosome was lost twice in two phylogenetic lineages of mole rats; before the event, a few male-specific genes escaped on X chromosomes. Translocations of Y chromosome fragments were made independently, resulting in different changes in species without a Y chromosome and the presence of the Y-linked Sry gene in females of E. fuscocapillus, a species retaining the Y chromosome. One more exceptional phenomenon is high autosomal variability in E. tancrei. This species might be used as an exclusive model for studying meiotic mechanisms providing balanced gametes in complex heterozygous hybrids. Sterility is the only destiny for hybrids, whose parents carry Robertsonian translocations with partial homology. Contrary to that, E. tancrei possess different Robertsonian translocations and successfully overcome the hybrid incompatibility. Here, we overview the research to date of sex determination and meiosis in Ellobius.
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.1803023
DO  - 10.21926/obm.genet.1803023
ID  - Bakloushinskaya2018
ER  -