TY  - JOUR
AU  - Oleson, David
AU  - Schaaf, Christian
AU  - Yin, Jiani
PY  - 2018
DA  - 2018/02/24
TI  - Next Generation Sequencing in Autism Spectrum Disorder
JO  - OBM Genetics
SP  - 014
VL  - 02
IS  - 01
AB  - Autism spectrum disorder is a clinically heterogeneous condition, characterized by social deficits, language impairment, repetitive behaviors, and restricted interest. Autism displays significant genetic heterogeneity. In the past one and a half decades, next generation sequencing has enabled identification of many variants that predispose to autism. These discoveries have improved understanding of the disease etiology of autism spectrum disorder. In this review article, we will address how development of next generation sequencing has helped answer the following questions: 1. What are the modes of transmission/inheritance of autism? 2. What is the nature of genetic mutations that contribute to autism? 3. Why is there a higher prevalence of autism in males than females?
SN  - 2577-5790
UR  - https://doi.org/10.21926/obm.genet.1801014
DO  - 10.21926/obm.genet.1801014
ID  - Oleson2018
ER  -