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Biography
Biography

Editor-in-Chief of OBM Hepatology and Gastroenterology

Osamu Yokosuka is an Emeritus Professor of Chiba University, Japan. He graduated from Chiba University School of Medicine in 1975 then worked as a trainee under Professor K. Okuda in Chiba University Hospital till 1978. Dr. Yokosuka was a research fellow worked under Professor S. Scherlock and Professor B. H. Billing in Royal Free Hospital, London, UK from 1978 to 1980; under Professor M. Omata in Chiba University from 1980 to 1985; and under Dr. J Summers in Fox Chase Cancer Center, PA, USA in 1984. In 1985, he received a Degree of Doctor of Medical Science, and served as an Assistant Professor in Chiba University till 1994, then as Lecturer in Medicine till 2006 when he was appointed as Director and Professor of Medicine. From 2013 to 2015, he served as the Dean of Chiba University School of Medicine.

Dr. Yokosuka was the Secretary General of APASL (2008-2014). In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. Dr. Yokosuka’s research mainly focuses on Hepatitis and Hepatocellular Carcinoma. So far, he has published more than 700 original papers.

Biography

The Associate Editor of OBM Hepatology and Gastroenterology

Tatsuo Kanda received a medical degree in 1991 at Niigata University School of Medicine, Japan, and his PhD in 1999 at Chiba University Graduate School of Medicine, Japan. He had post-doctor training for 3 years under Prof. Ratna Ray and Prof. Ranjit Ray at Saint Louis University, St. Louis, MO, USA. In Dec. 2008, Tatsuo Kanda became a Tenure-track Associate Professor at Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan. In Feb. 2013, Tatsuo Kanda was nominated a permanent Associate Professor at Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Japan. In 2017, Tatsuo Kanda became an Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine. For ~25 years, he has focused his scientific interests on the topics related to liver diseases including acute liver failure, viral hepatitis and autoimmune liver diseases, and worked with Prof. Osamu Yokosuka. Tatsuo Kanda is also an expert for hepatitis A virus (HAV), HBV and HCV, and translation and replication of these viruses, and hepatocarcinogenesis. With his expertise in antiviral therapies and hepatitis virus research, Tatsuo Kanda also sees a lot of patients in clinical daily practice. Tatsuo Kanda has published more than 200 articles in peer-reviewed Journal.

Special Issue

Multiple Aspects of Transplant Tolerance – Mechanisms, Strategies, and Barriers

Submission Deadline: September 30, 2018 (Open)                Submit Now

Guest Editor

Jean Kwun, PhD
Assistant Professor of Surgery, Duke Transplant Center, Department of Surgery, Duke University Medical Center, 207 Research Dr, Jones 362, Durham, NC 27710, USA
E-Mail: [email protected]
Website: https://surgery.duke.edu/faculty/jean-kwun-phd
Research Interests: heart transplantation, transplant tolerance, humoral tolerance to organ transplants, mechanisms of antibody-mediated rejection (AMR), establishing a conceptual basis that will translate into therapeutic intervention of AMR

About This Topic

The idea of immunological tolerance was developed from seminal works by Ray Owen, Sir F. MacFarlane Burnet, and Sir Peter Medawar in the mid-20th century. These findings drove transplantation research to identify mechanisms of immune tolerance. However, despite partial success, it was unable to stably induce tolerance in immunocompetent recipients. In the special issue, “Multiple Aspects of Transplant Tolerance”, we will provide a forum for presenting mechanisms, strategies, and challenges for promoting tolerance in transplantation. This will include description of cell populations plays a crucial role in tolerance as well as cell-based approaches (Treg, Mreg, DCreg, CD8 Treg, Tr1, and not excluding BM, apoptotic cell-based strategies), identification/validation of clinical tolerance strategy and biomarkers. Finally, we will also cover B cell immunobiology in transplantation and strategies for B cell and plasma cell tolerance. The special issue will also be open to any author, but mainly invited by guest editor. Each submission will be reviewed by at least two reviewers to ensure a very high quality of papers selected for the Special Issue.

Planned Papers

Title: Innate Immune Tolerance in Allo-transplantation
Authors: Andrea Carrion-Webster MD, Sunil Joshi DVM PhD, Asha Pillai MD

Title: Cell Based Therapies in Transplant Tolerance
Authors: Byoung Chol Oh, Giorgio Raimondi, Michael Grzelak

Title: Role of Chimerism Induction in Solid Organ Transplant
Authors: Jeffrey Dodd-o and Gerald Brandacher

Title: Tolerance in Clinical Liver Transplantation
Authors: Daniel Azoulay and Salim Hamdani

Title: Medawar's Paradox and Immune Mechanisms of Fetomaternal Tolerance
Authors: Victoria R. Rendell, MD and Todd V. Brennan, MD MS

Title: Clinical Tolerance induction trials – Where do we stand?
Authors: Antje Habicht, Joachim Andrassy

Title: T Cell Exhaustion: A Novel Mechanism of Transplant Tolerance
Authors: Zubair Ilyas, Mohammed Javeed I Ansari

Title: Transplantation for neurodegenerative diseases: strategies to overcome the tolerance barrier
Authors: Ludivine S Breger 1, Deirdre B Hoban 2, Emilie Faggiani 1
Affiliations:
1. Bordeaux University, France
2. Lund University, Sweden