01 - LIDSEN Publishing Inc.丨The Open Access Publisher

Volume 5,Issue 1

Open Access Review

Light-Activated Local Drug Delivery From Hydrogels: Potential for GBM Treatment

Lina Nguyen ,

Gabrielle Romena ,

Ethan Nguyen ,

Cassandra Tran ,

Kaitlyn Nguyen ,

Ananya Devarajan and

Henry Hirschberg

Received: 15 December 2020; Published: 23 March 2021; doi: 10.21926/obm.neurobiol.2101090

Abstract

Following post-operative treatment, the vast majority of GBMs recur, usually within 2 cm of the tumor resection margin. Since these tumors seldom metastasize outside the CNS, improved localized therapies should prove beneficial. Drug delivery systems (DDS) that allow control over drug release by an externally applied energy, such as light, have the potential of improving the results of chemotherapy. Light-activated hydrogel DDS, implanted in the operative cavity formed by tumor resection, bypass [...]

Open Access Case Report

Malignant Catatonia Requiring High Dose Bromocriptine: Case Report

Edwin Meresh ,

Clinton Korneffel ,

Bavani Rajah and

Ryan Bergren

Received: 23 December 2020; Published: 23 March 2021; doi: 10.21926/obm.neurobiol.2101089

Abstract

Catatonia can occur in patients diagnosed with schizophrenia and bipolar disorder and malignant catatonia is life threatening. Anti-psychotic medications should be discontinued during acute phase of catatonia. Anti-psychotic discontinuation in catatonia is a challenge in patients maintained on long-acting injectable antipsychotics because of the extended release. Case report: We present a case of malignant catatonia developed in a patient with history of schizophrenia and developmental delay. Sy [...]

Open Access Original Research

Smartphone Usage at Bedtime: The Effect of Sleep–Smartphone Hygiene, Trait Anxiety, and FOMO on Sleep Quality

Dorit Shoval ,

Nama Tal and

Orna Tzischinsky

Received: 21 July 2020; Published: 08 March 2021; doi: 10.21926/obm.neurobiol.2101088

Abstract

The present study was aimed to examine the relationship of sleep–smartphone hygiene, i.e., the habits of smartphone usage in the sleep environment, with the sleep quality among students and whether this relationship could be explained through psychological factors. A total of 467 Israeli college students were investigated using five questionnaires, namely, Sleep–Smartphone Hygiene Questionnaire (SSHQ), Fear of Missing Out Scale (FoMOs), Trait Anxiety Inventory (STAI-T), Pittsburgh Sleep Quality [...]

Open Access Review

Migraine as a Common Extra-Intestinal Presentation of Celiac Disease

Maurizio Gabrielli ,

Veronica Ojetti ,

Marcello Candelli ,

Luca Santarelli ,

Antonio Gasbarrini and

Francesco Franceschi

Received: 18 August 2020; Published: 09 February 2021; doi: 10.21926/obm.neurobiol.2101087

Abstract

Celiac disease (CD) is a common gluten-related enteropathy that presents several extra-intestinal manifestations. Migraine is globally recognized as one of the most diffuse primary headaches. The present paper aims to review the current evidence on the possible association between CD and migraine. Both adults and children having CD exhibit a high prevalence of migraine. However, screening for CD in an unselected population of migraineurs demonstrated contrasting results. Brain imaging may reveal [...]

Open Access Case Report

Case Report of Lambert Eaton Myasthenic Syndrome in a Patient with Small Cell Lung Cancer on Immune Checkpoint Inhibitor Therapy

Collin Anderson ,

Amanda Guidon ,

Farrah Khan ,

Alissa Thomas ,

Carolyne Riehle ,

Michael Hehir and

Noah Kolb

Received: 28 October 2020; Published: 31 January 2021; doi: 10.21926/obm.neurobiol.2101086

Abstract

Lambert Eaton myasthenic syndrome (LEMS) is a rare autoimmune neuromuscular junction disorder involving loss of functional pre-synaptic P/Q-type voltage-gated calcium channels. Many cases occur as a paraneoplastic disorder, often in small cell lung cancer (SCLC). Recently, immune checkpoint inhibitors (ICI) have emerged as treatment of choice for various malignancies. While generally well tolerated, certain ICI-treated patients experience neurologic immune-related adverse events (irAEs). Here, w [...]

Open Access Review

Prenatal and Preimplantation Genetic Diagnosis of Huntington's Disease

Joep Geraedts

Received: 15 December 2020; Published: 28 January 2021; doi: 10.21926/obm.neurobiol.2101085

Abstract

Huntington’s disease (HD) is an autosomal dominant disease that immensely impacts the affected families. However, the transmission of the disease from carriers to their offspring could be prevented. Prenatal diagnosis (PND) and preimplantation genetic diagnosis (PGD) are the only two available reproductive options for the carriers at risk to have disease-free children. PND for HD could be done through two kinds of genetic testing: direct and indirect. The same approaches are available for preimp [...]

Open Access Original Research

Quantum Theory of EEG with Application to the Single-Trial ERP Analysis

Dmitriy Melkonian

Received: 17 July 2020; Published: 27 January 2021; doi: 10.21926/obm.neurobiol.2101084

Abstract

The probabilistic formalism of quantum mechanics is used to quantitatively link the electroencephalogram (EEG) with the underlying microscale activity of cortical neurons. Previous approaches applied methods of classic physics to reconstruct the EEG in terms of explicit physical models of cortical neurons and the volume [...]

Open Access Research Article

N-Type Calcium Channels Control GABAergic Transmission in Brain Areas related to Fear and Anxiety

Maxwell Blazon ,

Brianna LaCarubba ,

Alexandra Bunda ,

Natalie Czepiel ,

Laura Londrigan ,

Shayna Mallat and

Arturo Andrade

Received: 13 September 2020; Published: 12 January 2021; doi: 10.21926/obm.neurobiol.2101083

Abstract

N-type (CaV2.2) calcium channels are key for action potential-evoked transmitter release in the peripheral and central nervous system. Previous studies have highlighted the functional relevance of N-type calcium channels at both the peripheral and central level. In the periphery, N-type calcium channels regulate nociceptive and sympathetic responses. At the central level, N-type calcium channels have been linked to aggression, hyperlocomotion, and anxiety. Among the areas of the brain that are i [...]

Open Access Communication

Medical Hypothesis: Deep Brain Stimulation for Intractable Migraine

Parisa Gazerani and

Brian Edwin Cairns

Received: 26 October 2020; Published: 05 January 2021; doi: 10.21926/obm.neurobiol.2101082

Abstract

Deep Brain Stimulation (DBS) has been introduced as an innovative treatment for several neurological disorders, including Parkinson’s disease, essential tremor, and dystonia and it has been proven effective in helping individuals affected by these disorders; hence, enhancing their quality of life. DBS has also been investigated for the treatment of cluster and other primary headaches. Electrodes are surgically implanted into brain structures, for example the posterior hypothalamus in case of clu [...]

Open Access Editorial

Acknowlegement to Reviewers of OBM Neurobiology in 2020

OBM Neurobiology

Received: 04 January 2021; Published: 05 January 2021; doi: 10.21926/obm.neurobiol.2101081

Abstract

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certifica [...]

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