Table of Contents

Volume 3,Issue 2

Open Access Review

Nonalcoholic Fatty Liver Disease and Inflammatory Bowel Disease: Complex Interactions, Evaluations, and Management Decisions

Received: 31 January 2019;  Published: 28 June 2019;  doi: 10.21926/obm.hg.1902025

Abstract

Diseases of the liver are commonly encountered in patients with Inflammatory Bowel Disease (IBD). While the differential for IBD patients with elevated liver associated enzymes is broad, it is similar to that of the general population. This differential includes including non-alcoholic fatty liver d [...]

Open Access Review

The Autotaxin - Lysophosphatidic Acid Axis as a Novel Therapeutic Target for Liver Fibrosis

Received: 27 March 2019;  Published: 21 June 2019;  doi: 10.21926/obm.hg.1902024

Abstract

Chronic liver diseases affects millions of people worldwide each year. Upon chronic liver injury, a wound healing process ensues, leading to the accumulation of extracellular matrix (ECM) proteins. If the injury persists, this leads to liver fibrosis with excessive scarring of the liver and loss of [...]

Open Access Review

Zinc in Liver Fibrosis

Received: 15 March 2019;  Published: 13 June 2019;  doi: 10.21926/obm.hg.1902023

Abstract

Acute and in particular chronic liver disease of viral, alcoholic and non-alcoholic genesis is a large, often unnoticed health hazard around the world. It can lead to cirrhosis and hepatocellular carcinoma (HCC) in the course of decades. Liver fibrosis, conversion of functional parenchyma to connect [...]

Open Access Review

Managing Acute Severe Necrotising Pancreatitis

Received: 25 February 2019;  Published: 05 June 2019;  doi: 10.21926/obm.hg.1902022

Abstract

Background: Severe necrotising pancreatitis (SNP) is characterised by high mortality, severe complications and bad prognosis despite progress in understanding of aetiology and progression of the disease. Traditionally, necrotic changes were removed by open necrosectomy but the paradigm has shifted t [...]

Open Access Opinion

The Curing of Crohn’s Disease

Received: 06 January 2019;  Published: 04 June 2019;  doi: 10.21926/obm.hg.1902021

Abstract

Using the therapeutic intervention points identified by the Hruska Postulate, the probability of curing Crohn’s disease through destroying the anti-MAP template is discussed.

Open Access Research Article

NF-κB; the Critical Link between Immune and Metabolic Pathways: Could NF-κB be Used as a Novel Diagnostic and Prognostic Biomarker for Non-Alcoholic Steatohepatitis?

Received: 28 January 2019;  Published: 22 May 2019;  doi: 10.21926/obm.hg.1902020

Abstract

(1) Background: A great number of inflammatory mediators and metabolic biomarkers have been shown to contribute to the development and progression of obesity-induced pathologies, including insulin resistance and nonalcoholic fatty liver disease (NAFLD). Many of those mediators are either targets or [...]

Open Access Review

Organotin Polymers for the Control of Pancreatic Cancer

Received: 31 January 2019;  Published: 14 May 2019;  doi: 10.21926/obm.hg.1902019

Abstract

Pancreatic cancer is the fourth leading cause of death in the USA. Treatment is seldom successful. A wide variety of organotin polymers exhibit good inhibition of human pancreatic cancer cell lines AsPC-1 and PANC-1. The AsPC-1 is an adenocarcinoma pancreatic cell line and PANC-1 which is an epit [...]

Open Access Review

The Rational Use of Diuretics in the Management of Cirrhotic Ascites in Japan

Received: 04 February 2019;  Published: 25 April 2019;  doi: 10.21926/obm.hg.1902018

Abstract

In cirrhosis, portal hypertension and hypoalbuminemia due to decreased albumin synthetic capacity and hormonal imbalance due to increased renin-angiotensin-aldosterone and vasopressin systems cause fluid retention and electrolyte abnormalities. Diuretics are indispensable for the control of body flu [...]

Open Access Review

Walled-Off Necrosis in Acute Pancreatitis: Clinical and Therapeutic Implications

Received: 07 February 2019;  Published: 10 April 2019;  doi: 10.21926/obm.hg.1902017

Abstract

Acute pancreatitis still represents a challenge for physicians; it ranges from mild self-limiting forms Walled-off necrosis (WON), previously called by other names, such as organized pancreatic necrosis, necroma, pancreatic sequestration, pseudocyst associated with necrosis and subacute pancreatic n [...]

Open Access Research Article

Prevalence of Viral Liver Disease and Oral Lichen Planus in Patients Who Visited Dental Clinics: A Study by the Ehime Dental Association

Received: 12 January 2019;  Published: 02 April 2019;  doi: 10.21926/obm.hg.1902016

Abstract

Background: The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP), an extrahepatic manifestation, is well known. There are still patients with viral liver disease in this country who are not receiving appropriate treatment. This prospective study aimed to evaluate th [...]

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