Current Issue 2018  Archive 2017 

Editor-in-Chief of OBM Hepatology and Gastroenterology

Osamu Yokosuka is an Emeritus Professor of Chiba University, Japan. He graduated from Chiba University School of Medicine in 1975 then worked as a trainee under Professor K. Okuda in Chiba University Hospital till 1978. Dr. Yokosuka was a research fellow worked under Professor S. Scherlock and Professor B. H. Billing in Royal Free Hospital, London, UK from 1978 to 1980; under Professor M. Omata in Chiba University from 1980 to 1985; and under Dr. J Summers in Fox Chase Cancer Center, PA, USA in 1984. In 1985, he received a Degree of Doctor of Medical Science, and served as an Assistant Professor in Chiba University till 1994, then as Lecturer in Medicine till 2006 when he was appointed as Director and Professor of Medicine. From 2013 to 2015, he served as the Dean of Chiba University School of Medicine.

Dr. Yokosuka was the Secretary General of APASL (2008-2014). In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. Dr. Yokosuka’s research mainly focuses on Hepatitis and Hepatocellular Carcinoma. So far, he has published more than 700 original papers.


The Associate Editor of OBM Hepatology and Gastroenterology

Tatsuo Kanda received a medical degree in 1991 at Niigata University School of Medicine, Japan, and his PhD in 1999 at Chiba University Graduate School of Medicine, Japan. He had post-doctor training for 3 years under Prof. Ratna Ray and Prof. Ranjit Ray at Saint Louis University, St. Louis, MO, USA. In Dec. 2008, Tatsuo Kanda became a Tenure-track Associate Professor at Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan. In Feb. 2013, Tatsuo Kanda was nominated a permanent Associate Professor at Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Japan. In 2017, Tatsuo Kanda became an Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine. For ~25 years, he has focused his scientific interests on the topics related to liver diseases including acute liver failure, viral hepatitis and autoimmune liver diseases, and worked with Prof. Osamu Yokosuka. Tatsuo Kanda is also an expert for hepatitis A virus (HAV), HBV and HCV, and translation and replication of these viruses, and hepatocarcinogenesis. With his expertise in antiviral therapies and hepatitis virus research, Tatsuo Kanda also sees a lot of patients in clinical daily practice. Tatsuo Kanda has published more than 200 articles in peer-reviewed Journal.

Special Issue

Health Modifiers of Neurocognitive Aging

Submission Deadline: November 30, 2018 (Open)               Submit Now

Guest Editor

Kamen Tsvetanov, PhD
Centre for Speech, Language and the Brain, Department of Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
E-Mail: [email protected]; [email protected]
Research Interests: Ageing; fMRI; neuroscience; connectomics; brain dynamics; cognitive neuroscience of ageing; relationship between human brain dynamics and cognition in healthy ageing and age-degenerative diseases

About This Topic

With the global demographic shift towards an older population, there is a pressing need to maintain mental wellbeing into late life, allowing people to work and live independently for longer. There are many influences on mental health which can be cultural, social, genetic, health and our own lifestyle decisions. These have an effect on our brain, and how well our brain works for what we call cognitive health – good memory, perception, language, judgement and so on.

The purpose of this Special Issue is to compile a number of selected research articles that focus on identifying factors for maintaining neurocognitive function across the lifespan – or ‘health modifiers’ – why some people seem to age without apparent adverse effects on their cognitive abilities, while others fare badly even without a dementia illness. In addition, this Special Issue welcomes review article submissions that critically assess the current knowledge on major health modifiers for mechanisms of neurocognitive aging. Addressing these issues has implications for understanding the influences that promote our brains process information to support mental functioning, throughout adult life.

Planned Papers

Title: Physical Activity and Cognitive Improvement on the Mini-Mental State Examination (MMSE): A Meta-Analysis
Authors: Ilse Schuitema and Ioanna Gkika
Abstract: The current meta-analysis focused on the cognitive improvement following various physical activity-based intervention programs, as measured by the Mini-Mental State Examination (MMSE). The included population suffered from mild cognitive impairment, mild or moderate dementia, or Alzheimer’s Disease, indicated by MMSE scores of 20-25, 10-20 or 0-10 respectively. Searching online databases (PubMed, PsycInfo and Embase) yielded 11 relevant studies, while 4 more were retrieved through individual searching. Only 5 studies reported pre and post intervention MMSE scores. With Comprehensive Meta-Analysis Software (CMA), the random effects model was used to calculate the summary effect of the five different randomized controlled trials. We found statistically significant positive post-intervention changes, i.e. improvements on MMSE scores regarding general cognitive status (Hedges’g = 0.75, p = 0.034), with large heterogeneity between studies (I2 = 78.40). The results of the current meta-analysis confirmed the relationship between physical activity and cognitive improvement in people with cognitive impairment. Further research into the details of this relationship, as well as to the clinical implications of this relationship, is needed.

Title: Behavioral and complementary interventions for Healthy Neurocognitive Aging
Authors: Robert L Conder, Christopher Friesen, Alanna A. Conder