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Journal Flyer

Current issue: 2018
Biography
Biography

Editor-in-Chief of OBM Hepatology and Gastroenterology

Osamu Yokosuka is an Emeritus Professor of Chiba University, Japan. He graduated from Chiba University School of Medicine in 1975 then worked as a trainee under Professor K. Okuda in Chiba University Hospital till 1978. Dr. Yokosuka was a research fellow worked under Professor S. Scherlock and Professor B. H. Billing in Royal Free Hospital, London, UK from 1978 to 1980; under Professor M. Omata in Chiba University from 1980 to 1985; and under Dr. J Summers in Fox Chase Cancer Center, PA, USA in 1984. In 1985, he received a Degree of Doctor of Medical Science, and served as an Assistant Professor in Chiba University till 1994, then as Lecturer in Medicine till 2006 when he was appointed as Director and Professor of Medicine. From 2013 to 2015, he served as the Dean of Chiba University School of Medicine.

Dr. Yokosuka was the Secretary General of APASL (2008-2014). In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. Dr. Yokosuka’s research mainly focuses on Hepatitis and Hepatocellular Carcinoma. So far, he has published more than 700 original papers.

Biography

The Associate Editor of OBM Hepatology and Gastroenterology

Tatsuo Kanda received a medical degree in 1991 at Niigata University School of Medicine, Japan, and his PhD in 1999 at Chiba University Graduate School of Medicine, Japan. He had post-doctor training for 3 years under Prof. Ratna Ray and Prof. Ranjit Ray at Saint Louis University, St. Louis, MO, USA. In Dec. 2008, Tatsuo Kanda became a Tenure-track Associate Professor at Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan. In Feb. 2013, Tatsuo Kanda was nominated a permanent Associate Professor at Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Japan. In 2017, Tatsuo Kanda became an Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine. For ~25 years, he has focused his scientific interests on the topics related to liver diseases including acute liver failure, viral hepatitis and autoimmune liver diseases, and worked with Prof. Osamu Yokosuka. Tatsuo Kanda is also an expert for hepatitis A virus (HAV), HBV and HCV, and translation and replication of these viruses, and hepatocarcinogenesis. With his expertise in antiviral therapies and hepatitis virus research, Tatsuo Kanda also sees a lot of patients in clinical daily practice. Tatsuo Kanda has published more than 200 articles in peer-reviewed Journal.

Special Issue

Epigenetic Mechanisms in Health and Disease

Submission Deadline: May 31, 2018 (Open)               Submit Now

Guest Editors

Stéphane Viville, PhD
Professor, LABORATOIRE DE DIAGNOSTIC GENETIQUE, UF3472 – Infertilité, Nouvel Hôpital Civil,
1 place de l’Hôpital, 67091 Strasbourg cedex, France
E-Mail: stephane.viville@unistra.fr
Website:  http://med.unistra.fr/eng/Recherche/Liste-des-Hospitalo-Universitaires/VIVILLE
Research Interests: human genetics of infertility; male and female infertility; human gametogenesis; human infertility and epigenetics; embryonic stem cells

Marcel Mannens, PhD
Professor, Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
E-Mails: m.a.mannens@amc.uva.nl; kg_dna@amc.uva.nl
Website: https://www.amc.nl/web/research-75/person-1/prof.-dr.-m.m.a.m.-mannens.htm
Research Interests: genome diagnostics; epigenetics of disease; cardiogenetics

Planned Papers

Title: Epigenetics and Human Reproduction
Author: Liborio Stuppia, MD1,2
Affiliation: 1. Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
2. Center for Aging Studies and Translational Medicine (CESI-MET), G. d’Annunzio University of Chieti-Pescara, Chieti, Italy, E-Mail: stuppia@unich.it
Abstract
In the frame of the large interest recently devoted to the role played by epigenetic regulation of gene expression in human health and disease, a key point is represented by the involvement of epigenetic modifications in human reproduction, in terms of reduced fertility, abnormalities of embryo development and risk of early and late onset diseases in the offspring. In fact, epigenetic mechanisms play a key role in the control of male and female gametogenesis, and alterations in the correct organization of DNA methylation, chromatin modelling and miRNA production can affect not only the fertility of the couple, but also, by intergenerational or transgenerational effects, the health of the offspring at birth or during lifetime. A further element of variability in human reproduction is represented by the increasing use of Assisted Reproduction Techniques (ART), in turn able to induce epigenetic modifications in the embryo and increase the risk of related disorders.
In this review, we analyse the different features of the correlation between epigenetics modification and human reproduction, describing not only the risks related to alterations of the epigenetic organization in male and female gamete, but also suggesting that the reversibility of the epigenetic processes could represent a novel resource for the treatment of the infertility of the couple.

Title: Update on Epigenetics Landscape in Parkinson Disease and Lewy Body Dementia
Author: Simon Chiu
Affiliation: Lawson Health Research Institute, London, Ontario, N6A 4V2, Canada

Title: Epigenetics in the actions of melatonin
Author: Ruediger Hardeland
Affiliation: Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Universitat Gottingen, Gottingen, Germany

Publication

Original Research

Evaluation of Recent Statistical Methods for Detecting Differential Methylation Using BS-seq Data

Chenggong Han, Hancong Tang, Shuyuan Lou, Yuan Gao, Min Ho Cho, Shili Lin
Received: May 23, 2018; Published: October 15, 2018; doi:10.21926/obm.genet.1804041

Review

Deciphering the Epigenetic Landscape of Suicidal Behaviour: A Review of Current Findings, Caveats and Future Directions

Stefania Policicchio, Emma L Dempster, Therese M Murphy
Received: June 20, 2018; Published: October 6, 2018; doi:10.21926/obm.genet.1804039

Review

Histone O-GlcNAcylation and Potential Biological Functions

Mitsuko Hirosawa, Koji Hayakawa, Kunio Shiota, Satoshi Tanaka
Received: July 5, 2018; Published: September 19, 2018; doi:10.21926/obm.genet.1803036

Review

Epigenetics of IgA Nephropathy: A Brief Review

Stamatia Stai
Received: May 27, 2018; Published: September 7, 2018; doi:10.21926/obm.genet.1803032

Review

Uniparental Disomy and Imprinting Disorders

Thomas Eggermann, Deborah J.G. Mackay, Zeynep Tümer
Received: June 28, 2018; Published: August 30, 2018; doi:10.21926/obm.genet.1803031

Research Article

New Insights into the Epigenetic Activities of Natural Compounds

Melita Vidakovic, Jessica Marinello, Maija Lahtela-Kakkonen, Daumantas Matulis, Vaida Linkuvienė, Benoît Y. Michel, Ruta Navakauskienė, Michael S. Christodoulou, Danielle Passarella, Saulius Klimasauskas, Christophe Blanquart, Muriel Cuendet, Judit Ovadi, Stéphane Poulain, Fabien Fontaine-Vive, Alain Burger, Nadine Martinet
Received: May 30, 2018; Published: August 16, 2018; doi:10.21926/obm.genet.1803029

Opinion

Runs of Homozygosity and Epigenetic Deregulation of Genomic Imprinting

Ivan Y. Iourov, Svetlana G. Vorsanova, Yuri B. Yurov
Received: May 29, 2018; Published: August 15, 2018; doi:10.21926/obm.genet.1803028

Research Article

Epigenetic Symmetry of DLGAP2: Pre-Implantation Maternal Methylation Switches to a Random Monoallelic Profile in Somatic Tissues

Ana Monteagudo-Sánchez, Marta Sánchez-Delgado, Sonia Guara Ciurana, Jose Medrano, Maria Eugenia Poo-Llanillo, Miho Ishida, Gudrun E. Moore, Isabel Iglesias-Platas, Carlos Simón, David Monk
Received: May 29, 2018; Published: July 30, 2018; doi:10.21926/obm.genet.1803026

Review

Non-Coding RNAs in Cutaneous Melanoma Development, Progression and Dissemination

Virginie Vignard, Delphine Fradin
Received: March 13, 2018; Published: May 16, 2018; doi:10.21926/obm.genet.1802020

Review

Current Understanding of DNA Methylation and Age-related Disease

Eunise M. Aquino, Miles C. Benton, Larisa M. Haupt, Heidi G. Sutherland, Lyn R. Griffiths, Rodney A. Lea
Received: February 12, 2018; Published: April 12, 2018; doi:10.21926/obm.genet.1802016

Review

The role of epigenetics in developmental programming and the developmental origins of health and disease

Kazuki Mochizuki, Chihiro Imai, Noriko Sato, Takeo Kubota
Received: June 20, 2017; Published: October 20, 2017; doi:10.21926/obm.genet.1703008