Table of Content

Open Access Review

“Evolution” of Embryogenesis: Complexity of the Early Developmental Stages in the Animal Kingdom

Steve Liebich
Received: March 16, 2020; Published: July 02, 2020; doi:10.21926/obm.genet.2003113

Abstract: Multicellularity has gained the advantage over the unicellular world by expanding the number of increasingly more complex tissues that achieve advanced and specific functions. This same event gave rise to the most evolved group of organisms, namely mammals. Even though the complexity of multicellula [...]

17 106

Open Access Original Research

Genetic Variants of Targetable Cancer-related Genes in Vestibular Schwannomas

Alvin Ho-Kwan Cheung, Nancy Bo-Yin Tsui, William Chi-Shing Cho, Xiao-Meng Pei, Yin-Kwan Evelyn Wong, Hin-Fung Andy Tsang, Gilberto Ka-Kit Leung, Sze-Chuen Cesar Wong
Received: May 02, 2020; Published: June 28, 2020; doi:10.21926/obm.genet.2002112

Abstract: Background: Vestibular schwannoma is an intracranial tumor which can lead to devastating neurological deficit and is prone to recurrence after surgery. Patients with inherited neurofibromatosis type 2 (NF2) syndrome are particularly susceptible to bilateral and aggressive schwannomas. However, the g [...]

25 156

Open Access Review

Genetic Explanations for Fertility Disorders

Joep Geraedts
Received: May 02, 2020; Published: June 23, 2020; doi:10.21926/obm.genet.2002111

Abstract: This article reviews the genetic testing of infertility disorders. Genetic abnormalities can lead to disturbances of sexual development and hamper reproduction by influencing gamete production and maturation, fertilization, and embryonic development. Until now, the vast majority of detectable geneti [...]

13 158

Open Access Review

Splicing HAC1/XBP1 mRNAs in Cytoplasm: The Non-Conventional mRNA Splicing Reaction in the Unfolded Protein Response

Yi Song, Carlos Rivera, Jiayu Mai, Annie Sun, Weihan Li
Received: March 23, 2020; Published: May 22, 2020; doi:10.21926/obm.genet.2002110

Abstract: The majority of the secretory and transmembrane proteins are folded in the endoplasmic reticulum (ER). When unfolded proteins accumulate in the ER, a collective of signalling pathways, termed the unfolded protein response (UPR), are activated to restore the ER protein folding homeostasis. The most e [...]

29 327

Open Access Technical Note

HER2 FISH for Breast Cancer: Advances in Quantitative Image Analysis and Automation

Jun Gu, Zhenya Tang, Hui Chen, Steven Sfamenos, Katherine B Geiersbach
Received: March 02, 2020; Published: May 13, 2020; doi:10.21926/obm.genet.2002109

Abstract: Quantitative image analysis of the status of human epidermal growth factor receptor 2 (HER2) by both immunohistochemistry staining and fluorescent in situ hybridization (FISH) is important for the treatment of breast cancer. Guidelines of the American Society for Clinical Oncology and College of Ame [...]

32 334

Open Access Research Article

Professionals’ Views on Offering Pre-Natal Testing for Adult Onset Cancer Susceptibility. Reconciling Personal and Professional Ethical Conflicts, Coping Strategies and Need for Policy Transparency

Lorraine Cowley, Mari Jones
Received: December 30, 2019; Published: April 26, 2020; doi:10.21926/obm.genet.2002108

Abstract: This paper explores views of healthcare professionals (HCPs) in genetics and foetal medicine settings on offering pre-natal diagnosis (PND) for adult onset cancer susceptibility (AOCS) genes. Study participants came from different disciplinary backgrounds and all had considered implications of offer [...]

31 337

Open Access Original Research

MSIGNET: A Bayesian Approach for Disease-associated Gene Network Identification

Xi Chen, Jianhua Xuan
Received: October 19, 2019; Published: April 07, 2020; doi:10.21926/obm.genet.2002107

Abstract: The analysis of gene networks and signalling pathways plays a key role in understanding gene functions, i.e., their effects on the development of a particular disease. Yet, for many heterogeneous diseases, the number of known disease-associated genes is limited. Identifying disease-assoc [...]

35 332

Open Access Case Report

Knight in Splicing Armor: Alternative Splicing as a Neuroprotective Mechanism

Joun Park, Xianzun Tao, R. Grace Zhai
Received: January 13, 2020; Published: March 20, 2020; doi:10.21926/obm.genet.2001106

Abstract: By adjusting gene expression in response to environmental changes, cells can optimize fitness as needed. Alternative splicing is one of the most important post-transcriptional regulation steps, broadly involved in diverse physiological and pathological conditions. Here, we present 5 case [...]

46 474

Open Access Editorial

Epigenetics of Obesity and Diabetes: Emerging Roles and Mechanisms of Non-coding RNAs

Mohamed Zaiou
Received: March 17, 2020; Published: March 17, 2020; doi:10.21926/obm.genet.2001105

53 436

Open Access Editorial

Plant Genetics and Gene Study

Yuri Shavrukov
Received: March 04, 2020; Published: March 04, 2020; doi:10.21926/obm.genet.2001104

67 445